Abstract
Serum from normal human subjects contained variable amounts of catalase activity, which was inhibitable by heat, azide, trichloroacetic acid (TCA), or aminotriazole treatment. Serum also decreased hydrogen peroxide (H2O2) concentrations in vitro and H2O2-mediated injury to cultured endothelial cells. By comparison, heat-, azide-, TCA-, or aminotriazole-treated serum neither decreased H2O2 concentrations in vitro nor reduced H2O2-mediated damage to endothelial cells. We conclude that serum catalase activity can alter H2O2-dependent reactions. We speculate that variations in serum catalase activity may alter individual susceptibility to oxidant-mediated vascular disease or be a factor when added to test systems in vitro.
Original language | English (US) |
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Pages (from-to) | 1903-1906 |
Number of pages | 4 |
Journal | Journal of applied physiology |
Volume | 71 |
Issue number | 5 |
DOIs | |
State | Published - 1991 |
Keywords
- antioxidants
- oxygen radicals
- peroxide
- vascular injury
ASJC Scopus subject areas
- General Medicine