Human-Specific Transcriptional Networks in the Brain

Genevieve Konopka, Tara Friedrich, Jeremy Davis-Turak, Kellen Winden, Michael C. Oldham, Fuying Gao, Leslie Chen, Guang Zhong Wang, Rui Luo, Todd M. Preuss, Daniel H. Geschwind

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Understanding human-specific patterns of brain gene expression and regulation can provide key insights into human brain evolution and speciation. Here, we use next-generation sequencing, and Illumina and Affymetrix microarray platforms, to compare the transcriptome of human, chimpanzee, and macaque telencephalon. Our analysis reveals a predominance of genes differentially expressed within human frontal lobe and a striking increase in transcriptional complexity specific to the human lineage in the frontal lobe. In contrast, caudate nucleus gene expression is highly conserved. We also identify gene coexpression signatures related to either neuronal processes or neuropsychiatric diseases, including a human-specific module with CLOCK as its hub gene and another module enriched for neuronal morphological processes and genes coexpressed with FOXP2, a gene important for language evolution. These data demonstrate that transcriptional networks have undergone evolutionary remodeling even within a given brain region, providing a window through which to view the foundation of uniquely human cognitive capacities.

Original languageEnglish (US)
Pages (from-to)601-617
Number of pages17
JournalNeuron
Volume75
Issue number4
DOIs
StatePublished - Aug 23 2012

Fingerprint

Gene Regulatory Networks
Brain
Frontal Lobe
Genes
Telencephalon
Pan troglodytes
Caudate Nucleus
Gene Expression Regulation
Macaca
Transcriptome
Language
Gene Expression

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Konopka, G., Friedrich, T., Davis-Turak, J., Winden, K., Oldham, M. C., Gao, F., ... Geschwind, D. H. (2012). Human-Specific Transcriptional Networks in the Brain. Neuron, 75(4), 601-617. https://doi.org/10.1016/j.neuron.2012.05.034

Human-Specific Transcriptional Networks in the Brain. / Konopka, Genevieve; Friedrich, Tara; Davis-Turak, Jeremy; Winden, Kellen; Oldham, Michael C.; Gao, Fuying; Chen, Leslie; Wang, Guang Zhong; Luo, Rui; Preuss, Todd M.; Geschwind, Daniel H.

In: Neuron, Vol. 75, No. 4, 23.08.2012, p. 601-617.

Research output: Contribution to journalArticle

Konopka, G, Friedrich, T, Davis-Turak, J, Winden, K, Oldham, MC, Gao, F, Chen, L, Wang, GZ, Luo, R, Preuss, TM & Geschwind, DH 2012, 'Human-Specific Transcriptional Networks in the Brain', Neuron, vol. 75, no. 4, pp. 601-617. https://doi.org/10.1016/j.neuron.2012.05.034
Konopka G, Friedrich T, Davis-Turak J, Winden K, Oldham MC, Gao F et al. Human-Specific Transcriptional Networks in the Brain. Neuron. 2012 Aug 23;75(4):601-617. https://doi.org/10.1016/j.neuron.2012.05.034
Konopka, Genevieve ; Friedrich, Tara ; Davis-Turak, Jeremy ; Winden, Kellen ; Oldham, Michael C. ; Gao, Fuying ; Chen, Leslie ; Wang, Guang Zhong ; Luo, Rui ; Preuss, Todd M. ; Geschwind, Daniel H. / Human-Specific Transcriptional Networks in the Brain. In: Neuron. 2012 ; Vol. 75, No. 4. pp. 601-617.
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