Human x mouse hybrid cells segregating mouse chromosomes and isozymes

John D. Minna, Hayden G. Coon

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

THE usual pattern of chromosome segregation in interspecific human×mouse somatic cell hybrids is retention of mouse and loss of human chromosomes1. In attempts to generate hybrid strains expressing differentiated functions, we have fused an actively dividing human cell line with freshly dissociated, highly differentiated cells from the mouse embryonic nervous system. The majority of the resulting hybrid strains retain human while losing mouse chromosomes and isozymes and thus provide a new class of hybrid cell for analysis of gene linkage and regulation.

Original languageEnglish (US)
Pages (from-to)401-404
Number of pages4
JournalNature
Volume252
Issue number5482
DOIs
StatePublished - Dec 1 1974

ASJC Scopus subject areas

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