Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis

Youcai Hu; Kezhan Wang; John B. MacMillan

doi:10.1021/ol303376c

Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis

Youcai Hu, Kezhan Wang, John B. MacMillan

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Hunanamycin A, the first natural product with a pyrido[1,2,3-de] quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.

Original language	English (US)
Pages (from-to)	390-393
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	2
DOIs	https://doi.org/10.1021/ol303376c
State	Published - Jan 18 2013

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol303376c

Cite this

@article{d129102a7d704bb2984d45174dd85999,

title = "Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis",

abstract = "Hunanamycin A, the first natural product with a pyrido[1,2,3-de] quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.",

author = "Youcai Hu and Kezhan Wang and MacMillan, {John B.}",

year = "2013",

month = jan,

day = "18",

doi = "10.1021/ol303376c",

language = "English (US)",

volume = "15",

pages = "390--393",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis

AU - Hu, Youcai

AU - Wang, Kezhan

AU - MacMillan, John B.

PY - 2013/1/18

Y1 - 2013/1/18

N2 - Hunanamycin A, the first natural product with a pyrido[1,2,3-de] quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.

AB - Hunanamycin A, the first natural product with a pyrido[1,2,3-de] quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.

UR - http://www.scopus.com/inward/record.url?scp=84872592159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872592159&partnerID=8YFLogxK

U2 - 10.1021/ol303376c

DO - 10.1021/ol303376c

M3 - Article

C2 - 23305153

AN - SCOPUS:84872592159

SN - 1523-7060

VL - 15

SP - 390

EP - 393

JO - Organic Letters

JF - Organic Letters

IS - 2

ER -

Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this