Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis

Youcai Hu, Kezhan Wang, John B. MacMillan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Hunanamycin A, the first natural product with a pyrido[1,2,3-de] quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.

Original languageEnglish (US)
Pages (from-to)390-393
Number of pages4
JournalOrganic Letters
Volume15
Issue number2
DOIs
StatePublished - Jan 18 2013

Fingerprint

antibiotics
Bacillus
Bacilli
riboflavin
Anti-Bacterial Agents
salmonella
quinoxalines
pathogens
stereochemistry
Dione
products
Prenylation
Quinoxalines
Stereochemistry
Salmonella
Salmonella enterica
Riboflavin
Cyclization
Microbial Sensitivity Tests
Pathogens

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis. / Hu, Youcai; Wang, Kezhan; MacMillan, John B.

In: Organic Letters, Vol. 15, No. 2, 18.01.2013, p. 390-393.

Research output: Contribution to journalArticle

Hu, Youcai ; Wang, Kezhan ; MacMillan, John B. / Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis. In: Organic Letters. 2013 ; Vol. 15, No. 2. pp. 390-393.
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