Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis

Youcai Hu, Kezhan Wang, John B. MacMillan

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Hunanamycin A, the first natural product with a pyrido[1,2,3-de] quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.

Original languageEnglish (US)
Pages (from-to)390-393
Number of pages4
JournalOrganic Letters
Volume15
Issue number2
DOIs
StatePublished - Jan 18 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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