Huntington’s disease: Cellular and molecular basis of pathology

V. V. Korzhova, D. N. Artamonov, O. L. Vlasova, I. B. Bezprozvanny

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by a polyQ expansion (>36 glutamine repeats) in Huntingtin (Htt) protein. It is believed that dysfunction of corticostriatal system is one of the main pathological events. Special attention is paid to synaptic dysfunction of transmission between cortical and striatal neurons. This review focuses on modern concepts of molecular and cellular mechanisms of HD pathology and especially on alterations in corticostriatal connectivity. Calcium hypothesis of HD and new pharmacological targets are described.

Original languageEnglish (US)
Pages (from-to)359-375
Number of pages17
JournalZhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume64
Issue number4
DOIs
StatePublished - Jan 1 2014

Keywords

  • Dendritic spines
  • Huntington’s disease
  • Striatum
  • Synaptic transmission

ASJC Scopus subject areas

  • Neuroscience(all)

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