Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism

Yi Zhu, Ilja L. Kruglikov, Yucel Akgul, Philipp E. Scherer

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Hyaluronic acid (HA, also known as hyaluronan), is a non-sulfated linear glycosaminoglycan polymer consisting of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine abundantly present in the extracellular matrix. The sizes of hyaluronic acid polymers range from 5000 to 20,000,000 Da in vivo, and the functions of HA are largely dictated by its size. Due to its high biocompatibility, HA has been commonly used as soft tissue filler as well as a major component of biomaterial scaffolds in tissue engineering. Several studies have implicated that HA may promote differentiation of adipose tissue derived stem cells in vitro or in vivo when used as a supporting scaffold. However, whether HA actually promotes adipogenesis in vivo and the subsequent metabolic effects of this process are unclear. This review summarizes some recent publications in the field and discusses the possible directions and approaches for future studies, focusing on the role of HA in the adipose tissue.

Original languageEnglish (US)
Pages (from-to)284-291
Number of pages8
JournalMatrix Biology
StatePublished - May 2019


  • Adipogenesis
  • Adipose tissue
  • Dermal filler
  • Extracellular matrix
  • Hyaluronan
  • Hyaluronic acid

ASJC Scopus subject areas

  • Molecular Biology


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