Hydrogen peroxide contrast echocardiography

F. Andrew Gaffney, Jui Chin Lin, Ronald M Peshock, Larry Bush, L. Maximilian Buja

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Several agents are used as echocardiographic contrast agents, but their unreliability discourages routine clinical use. Studies from the early 1960s suggest that dilute hydrogen peroxide (H2O2) is a safe intravascular agent. Its use was evaluated in contrast echocardiography. To obtain dense opacification reliably, H2O2 (3%) was passed through a sterile 0.2 μ Millipore filter and diluted with heparinized saline solution to make a 0.1 to 0.2% solution. A drop of blood was withdrawn from an indwelling peripheral venous needle into a syringe containing 0.5 to 2.0 ml of the dilute H2O2 and the contents injected. Studies in dogs, normal adults and 36 patients with noncyanotic congenital and acquired cardiac disorders produced dense opacification with no complications. In vitro mixture of H2O2 (0.3%) with leukocyte-poor blood or plasma produced only a few microbubbles, while addition to whole blood or buffy coat produced many, suggesting a role for leukocyte peroxidase. H2O2 contrast echocardiography is simple, inexpensive, and reliably provides dense, sustained opacification. This study and previous studies suggest that intravenous injection of 0.2% H2O2 can be done safely. Great caution should be exercised in patients with severe pulmonary hypertension or large right-to-left shunts because little clinical experience with H2O2 is available.

Original languageEnglish (US)
Pages (from-to)607-609
Number of pages3
JournalThe American Journal of Cardiology
Volume52
Issue number5
DOIs
StatePublished - Sep 1 1983

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Hydrogen Peroxide
Echocardiography
Leukocytes
Blood Buffy Coat
Micropore Filters
Microbubbles
Syringes
Pulmonary Hypertension
Sodium Chloride
Intravenous Injections
Contrast Media
Peroxidase
Needles
Dogs
In Vitro Techniques

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hydrogen peroxide contrast echocardiography. / Gaffney, F. Andrew; Lin, Jui Chin; Peshock, Ronald M; Bush, Larry; Buja, L. Maximilian.

In: The American Journal of Cardiology, Vol. 52, No. 5, 01.09.1983, p. 607-609.

Research output: Contribution to journalArticle

Gaffney, F. Andrew ; Lin, Jui Chin ; Peshock, Ronald M ; Bush, Larry ; Buja, L. Maximilian. / Hydrogen peroxide contrast echocardiography. In: The American Journal of Cardiology. 1983 ; Vol. 52, No. 5. pp. 607-609.
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