Hydroxamic derivatives of saturated fatty acids as inhibitors of 5-lipoxygenase

L. V. Bondarenko, S. A. Ohiy, V. N. Tsernjuk, I. A. Butovich

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In experiments in vitro were established inhibitory effects ofhydroxamic derivatives ofstearic, palmitic and caprilic acids on 5-lipoxygenase from potato tubers. Their effects depended on pli and substrate concentrations and were independent - on time of incubation of enzyme with inhibitor. Hydroxamic derivative of stearic acid was the most effective inhibitor among investigated compounds. Sliortening of fatty acid side chain lead to sharp decreasing of inhibitory effect.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalBiopolymers and Cell
Volume12
Issue number2
DOIs
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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