Hydroxyapatite and tricalcium phosphate bone graft substitutes

R. W. Bucholz, A. Carlton, R. E. Holmes

Research output: Contribution to journalArticle

295 Scopus citations


Autografts have consistently outperformed calcium phosphate implants in most experimental models and clinical applications. However, human trials in metaphyseal defects demonstrate comparable results with autograft, hydroxyapatite, and TCP. Diaphyseal fractures and segmental defects represent more challenging problems, with less predictable results achieved with the synthetic bone graft substitutes. Improvements in the pore configuration, mechanical properties, and osteoinductive capacity of these implants should widen their future clinical application.

Original languageEnglish (US)
Pages (from-to)323-334
Number of pages12
JournalOrthopedic Clinics of North America
Issue number2
Publication statusPublished - 1987


ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Bucholz, R. W., Carlton, A., & Holmes, R. E. (1987). Hydroxyapatite and tricalcium phosphate bone graft substitutes. Orthopedic Clinics of North America, 18(2), 323-334.