Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease

Javier Bolaños-Meade, Lan Zhou, Ahmet Hoke, Andrea Corse, Georgia Vogelsang, Kathryn R. Wagner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine.

Original languageEnglish (US)
Pages (from-to)306-309
Number of pages4
JournalAmerican Journal of Hematology
Volume78
Issue number4
DOIs
StatePublished - Apr 1 2005

Fingerprint

Hydroxychloroquine
Graft vs Host Disease
Muscular Diseases
Mantle-Cell Lymphoma
Respiratory Muscles
Polyneuropathies
Muscle Weakness
Electromyography
Cholinergic Receptors
Creatine Kinase
Vacuoles
Extremities
Bone Marrow
Transplants
Biopsy
Muscles
Antibodies
Serum
Pharmaceutical Preparations
Vacuolar myopathy

Keywords

  • Graft-versus-host disease
  • Hydroxychloroquine
  • Myopathy
  • Vacuolar myopathy

ASJC Scopus subject areas

  • Hematology

Cite this

Bolaños-Meade, J., Zhou, L., Hoke, A., Corse, A., Vogelsang, G., & Wagner, K. R. (2005). Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease. American Journal of Hematology, 78(4), 306-309. https://doi.org/10.1002/ajh.20294

Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease. / Bolaños-Meade, Javier; Zhou, Lan; Hoke, Ahmet; Corse, Andrea; Vogelsang, Georgia; Wagner, Kathryn R.

In: American Journal of Hematology, Vol. 78, No. 4, 01.04.2005, p. 306-309.

Research output: Contribution to journalArticle

Bolaños-Meade, J, Zhou, L, Hoke, A, Corse, A, Vogelsang, G & Wagner, KR 2005, 'Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease', American Journal of Hematology, vol. 78, no. 4, pp. 306-309. https://doi.org/10.1002/ajh.20294
Bolaños-Meade, Javier ; Zhou, Lan ; Hoke, Ahmet ; Corse, Andrea ; Vogelsang, Georgia ; Wagner, Kathryn R. / Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease. In: American Journal of Hematology. 2005 ; Vol. 78, No. 4. pp. 306-309.
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