Hyperaggregation of platelets detected by whole blood platelet aggregometry in newly diagnosed noninsulin-dependent diabetes mellitus

S. Mandal, R. Sarode, S. Dash, R. J. Dash

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Twenty-five newly diagnosed cases of noninsulin-dependent diabetes mellitus were studied at the time of diagnosis and again after metabolic control of diabetes was achieved (approximately 3 months later) for platelet aggregation abnormalities in whole blood by the impedance method. Adenosine diphosphate in 10 and 20 μmol/L final concentrations and arachidonic acid in 25 and 50 μmol/L final concentrations were used as agonists. Patients had a significant hyperaggregation of platelets (P < 0.01) at the time of diagnosis compared with age-matched healthy control subjects. After metabolic control of blood glucose was achieved using oral hypoglycemic agents (n = 20) and diet regulation alone (n = 5), there was a significant decrease in platelet aggregation (P < 0.01). There was a positive relationship between blood glucose levels and whole blood platelet aggregation with adenosine diphosphate (P < 0.02 and < 0.05, with 10 μmol/L and 20 μmol/L, respectively), but there was no relationship between aggregation and glycosylated hemoglobin levels. Thus, platelet hyperaggregation was present even at the time of diagnosis in patients with diabetes mellitus in the absence of any vascular complications, and there was significant improvement in platelet hyperaggregation after metabolic control of blood glucose levels was achieved.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalAmerican journal of clinical pathology
Volume100
Issue number2
DOIs
StatePublished - Jan 1 1993

Keywords

  • Noninsulin-dependent diabetes mellitus
  • Platelet aggregation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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