Hypercholesterolemia in elderly persons: Resolving the treatment dilemma

Margo A. Denke, Scott M Grundy

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Of all age groups, men and women over 60 years of age have the highest prevalence of elevated serum cholesterol levels. Now that detection and treatment of high serum cholesterol levels are increasing, we need a rational approach to managing elevated cholesterol levels in elderly patients. Recent data indicate that high total cholesterol and low-density lipoprotein levels predict risk for coronary heart disease in patients over 60 years of age. However, selecting appropriate candidates for cholesterol-lowering therapy requires clinical judgment of the relative risks and benefits of each therapy and consideration of each patient's overall health status as well as of competing risks. Active medical management of high cholesterol levels, therefore, should be restricted to a limited fraction of elderly patients who are most likely to benefit from long-term therapy. The first line of treatment is diet modification; however, drug therapy for appropriate patients is not contraindicated because of age alone.

Original languageEnglish (US)
Pages (from-to)780-792
Number of pages13
JournalAnnals of Internal Medicine
Volume112
Issue number10
StatePublished - May 15 1990

Fingerprint

Hypercholesterolemia
Diet Therapy
Therapeutics
Serum
LDL Cholesterol
Health Status
Coronary Disease
Age Groups
Cholesterol
Drug Therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hypercholesterolemia in elderly persons : Resolving the treatment dilemma. / Denke, Margo A.; Grundy, Scott M.

In: Annals of Internal Medicine, Vol. 112, No. 10, 15.05.1990, p. 780-792.

Research output: Contribution to journalArticle

@article{6a546aa1a14a4f168461fef2c52ea1e5,
title = "Hypercholesterolemia in elderly persons: Resolving the treatment dilemma",
abstract = "Of all age groups, men and women over 60 years of age have the highest prevalence of elevated serum cholesterol levels. Now that detection and treatment of high serum cholesterol levels are increasing, we need a rational approach to managing elevated cholesterol levels in elderly patients. Recent data indicate that high total cholesterol and low-density lipoprotein levels predict risk for coronary heart disease in patients over 60 years of age. However, selecting appropriate candidates for cholesterol-lowering therapy requires clinical judgment of the relative risks and benefits of each therapy and consideration of each patient's overall health status as well as of competing risks. Active medical management of high cholesterol levels, therefore, should be restricted to a limited fraction of elderly patients who are most likely to benefit from long-term therapy. The first line of treatment is diet modification; however, drug therapy for appropriate patients is not contraindicated because of age alone.",
author = "Denke, {Margo A.} and Grundy, {Scott M}",
year = "1990",
month = "5",
day = "15",
language = "English (US)",
volume = "112",
pages = "780--792",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "10",

}

TY - JOUR

T1 - Hypercholesterolemia in elderly persons

T2 - Resolving the treatment dilemma

AU - Denke, Margo A.

AU - Grundy, Scott M

PY - 1990/5/15

Y1 - 1990/5/15

N2 - Of all age groups, men and women over 60 years of age have the highest prevalence of elevated serum cholesterol levels. Now that detection and treatment of high serum cholesterol levels are increasing, we need a rational approach to managing elevated cholesterol levels in elderly patients. Recent data indicate that high total cholesterol and low-density lipoprotein levels predict risk for coronary heart disease in patients over 60 years of age. However, selecting appropriate candidates for cholesterol-lowering therapy requires clinical judgment of the relative risks and benefits of each therapy and consideration of each patient's overall health status as well as of competing risks. Active medical management of high cholesterol levels, therefore, should be restricted to a limited fraction of elderly patients who are most likely to benefit from long-term therapy. The first line of treatment is diet modification; however, drug therapy for appropriate patients is not contraindicated because of age alone.

AB - Of all age groups, men and women over 60 years of age have the highest prevalence of elevated serum cholesterol levels. Now that detection and treatment of high serum cholesterol levels are increasing, we need a rational approach to managing elevated cholesterol levels in elderly patients. Recent data indicate that high total cholesterol and low-density lipoprotein levels predict risk for coronary heart disease in patients over 60 years of age. However, selecting appropriate candidates for cholesterol-lowering therapy requires clinical judgment of the relative risks and benefits of each therapy and consideration of each patient's overall health status as well as of competing risks. Active medical management of high cholesterol levels, therefore, should be restricted to a limited fraction of elderly patients who are most likely to benefit from long-term therapy. The first line of treatment is diet modification; however, drug therapy for appropriate patients is not contraindicated because of age alone.

UR - http://www.scopus.com/inward/record.url?scp=0025316371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025316371&partnerID=8YFLogxK

M3 - Article

C2 - 2184712

AN - SCOPUS:0025316371

VL - 112

SP - 780

EP - 792

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 10

ER -