Hyperdiploidy including trisomy 8 in a cystic partially differentiated nephroblastoma

Charles F. Timmons, Loris McGavran, Linda Unterkircher, J. Bruce Beckwith, Harry L. Wilson

Research output: Contribution to journalArticle

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Abstract

Cystic partially differentiated nephroblastoma (CPDN), a rare, cystic, renal lesion of childhood, has not been previously karyotyped. It is distinguished histologically from multilocular renal cyst by the presence of blastemal cells, and from Wilms' tumor by lack of expansile, solid growth and by indolent clinical behavior. In the present case, ten of 20 analyzed cells from a 3-week culture obtained from the tumor had a clonal, hyperdiploid karyotype. The modal chromosome number was 51, with chromosomes 8, 12, 17, 19, and 20 usually being present in three copies. Trisomy 8 was present in every hyperdiploid cell examined. A normal 46,XY constitutional karyotype was also observed. In degree and significance, the hyperdiploidy of CPDN is thus distinct from that reported in the prognostically unfavorable, anaplastic Wilms' tumor, where the DNA index is typically near-tetraploid. Trisomy 8, as a constitutional mosaicism, has been previously reported in children with bilateral CPDN and/or undifferentiated sarcomas, although none of their tumors were karyotyped. The present findings support a neoplastic nature for CPDN, while emphasizing its pathogenetic distinctiveness from Wilms' tumor, and provide further evidence for significance of trisomy 8 in the pathobiology of this tumor.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume41
Issue number1
DOIs
StatePublished - 1989

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Polyploidy
Wilms Tumor
Karyotype
Kidney
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 8
Neoplasms
Mosaicism
Tetraploidy
Trisomy Chromosome 8
Sarcoma
Cysts
Chromosomes
DNA
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Hyperdiploidy including trisomy 8 in a cystic partially differentiated nephroblastoma. / Timmons, Charles F.; McGavran, Loris; Unterkircher, Linda; Bruce Beckwith, J.; Wilson, Harry L.

In: Cancer Genetics and Cytogenetics, Vol. 41, No. 1, 1989, p. 79-85.

Research output: Contribution to journalArticle

Timmons, Charles F. ; McGavran, Loris ; Unterkircher, Linda ; Bruce Beckwith, J. ; Wilson, Harry L. / Hyperdiploidy including trisomy 8 in a cystic partially differentiated nephroblastoma. In: Cancer Genetics and Cytogenetics. 1989 ; Vol. 41, No. 1. pp. 79-85.
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