Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction

J. L. Goldstein, W. R. Hazzard, H. G. Schrott, E. L. Bierman, A. G. Motulsky

Research output: Contribution to journalArticle

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Abstract

Plasma cholesterol and triglyceride levels were measured after an overnight fast in 500 consecutively studied 3 mth survivors of myocardial infarction. Virtually all patients under 60 yr of age (95% ascertainment) and a randomly chosen group of older survivors admitted to 13 Seattle hospitals during an 11 mth period were included. A comparison of their lipid values with those of 950 controls demonstrated that 31% had hyperlipidemia. These lipid abnormalities were most commonly found in males under 40 yr of age (60% frequency) and in females under 50 yr of age (60% frequency). Elevation in triglyceride levels with (7.8%) or without (15.6%) an associated elevation in cholesterol levels was three times more common in survivors than a high cholesterol level alone (7.6%). These results raise the possibility that hypertriglyceridemia may be as an important a risk factor for coronary atherosclerosis as hypercholesterolemia. The identification of hyperlipidemic survivors of myocardial infarction provided a unique source of probands for family studies designed to disclose the genetic origin of hyperlipidemia in coronary heart disease.

Original languageEnglish (US)
Pages (from-to)1533-1543
Number of pages11
JournalJournal of Clinical Investigation
Volume52
Issue number7
StatePublished - 1973

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Hyperlipidemias
Coronary Disease
Survivors
Myocardial Infarction
Hypercholesterolemia
Triglycerides
Cholesterol
Lipids
Hypertriglyceridemia
Coronary Artery Disease
lipid I

ASJC Scopus subject areas

  • Medicine(all)

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Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. / Goldstein, J. L.; Hazzard, W. R.; Schrott, H. G.; Bierman, E. L.; Motulsky, A. G.

In: Journal of Clinical Investigation, Vol. 52, No. 7, 1973, p. 1533-1543.

Research output: Contribution to journalArticle

Goldstein, JL, Hazzard, WR, Schrott, HG, Bierman, EL & Motulsky, AG 1973, 'Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction', Journal of Clinical Investigation, vol. 52, no. 7, pp. 1533-1543.
Goldstein, J. L. ; Hazzard, W. R. ; Schrott, H. G. ; Bierman, E. L. ; Motulsky, A. G. / Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. In: Journal of Clinical Investigation. 1973 ; Vol. 52, No. 7. pp. 1533-1543.
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