Hyperpolarized magnetic resonance as a sensitive detector of metabolic function

Arnaud Comment, Matthew E. Merritt

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Hyperpolarized magnetic resonance allows for noninvasive measurements of biochemical reactions in vivo. Although this technique provides a unique tool for assaying enzymatic activities in intact organs, the scope of its application is still elusive for the wider scientific community. The purpose of this review is to provide key principles and parameters to guide the researcher interested in adopting this technology to address a biochemical, biomedical, or medical issue. It is presented in the form of a compendium containing the underlying essential physical concepts as well as suggestions to help assess the potential of the technique within the framework of specific research environments. Explicit examples are used to illustrate the power as well as the limitations of hyperpolarized magnetic resonance.

Original languageEnglish (US)
Pages (from-to)7333-7357
Number of pages25
JournalBiochemistry
Volume53
Issue number47
DOIs
StatePublished - Dec 2 2014

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Magnetic resonance
Magnetic Resonance Spectroscopy
Physical Phenomena
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  • Biochemistry

Cite this

Hyperpolarized magnetic resonance as a sensitive detector of metabolic function. / Comment, Arnaud; Merritt, Matthew E.

In: Biochemistry, Vol. 53, No. 47, 02.12.2014, p. 7333-7357.

Research output: Contribution to journalArticle

Comment, Arnaud ; Merritt, Matthew E. / Hyperpolarized magnetic resonance as a sensitive detector of metabolic function. In: Biochemistry. 2014 ; Vol. 53, No. 47. pp. 7333-7357.
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