Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients

Physiological relevance in older never-and ex-smokers

Miranda Kirby, Alexei Ouriadov, Sarah Svenningsen, Amir Owrangi, Andrew Wheatley, Roya Etemad-Rezai, Giles E. Santyr, David G. McCormack, Grace Parraga

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Noble gas pulmonary magnetic resonance imaging (MRI) is transitioning away from3He to129Xe gas, but the physiological/clinical relevance of129Xe apparent diffusion coefficient (ADC) parenchyma measurements is not well understood. Therefore, our objective was to generate129Xe MRI ADC for comparison with3He ADC and with well-established measurements of alveolar structure and function in older never-smokers and ex-smokers with chronic obstructive pulmonary disease (COPD). In four never-smokers and 10 COPD ex-smokers,3He (b = 1.6 sec/cm2) and129Xe (b = 12, 20, and 30 sec/ cm2) ADC, computed tomography (CT) density-threshold measurements, and the diffusing capacity for carbon monoxide (DLCO) were measured. To understand regional differences, the anterior-posterior (APG) and superior-inferior (ΔSI) ADC differences were evaluated. Compared to never-smokers, COPD ex-smokers showed greater3He ADC (P = 0.006),129Xe ADCb12 (P = 0.006), and ADCb20 (P = 0.006), but not for ADCb30 (P > 0.05). Never-smokers and COPD ex-smokers had significantly different APG for3He ADC (P = 0.02),129Xe ADCb12 (P = 0.006), and ADCb20 (P = 0.01), but not for ADCb30 (P > 0.05). ΔSI for never-and ex-smokers was significantly different for3He ADC (P = 0.046), but not for129Xe ADC (P > 0.05). There were strong correlations for DLCO with3He ADC and129Xe ADCb12 (both r = −0.95, P < 0.05); in a multivariate model129Xe ADCb12 was the only significant predictor of DLCO (P = 0.049). For COPD ex-smokers, CT relative area <_950 HU (RA950) correlated with3He ADC (r = 0.90, P = 0.008) and129Xe ADCb12 (r = 0.85, P = 0.03). In conclusion, while129Xe ADCb30 may be appropriate for evaluating subclinical or mild emphysema, in this small group of never-smokers and ex-smokers with moderate-to-severe emphysema,129Xe ADCb12 provided a physiologically appropriate estimate of gas exchange abnormalities and alveolar microstructure.

Original languageEnglish (US)
Article numbere12068
JournalPhysiological Reports
Volume2
Issue number7
DOIs
StatePublished - Jan 1 2014

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Diffusion Magnetic Resonance Imaging
Chronic Obstructive Pulmonary Disease
Emphysema
Gases
Tomography
Noble Gases
Carbon Monoxide
Magnetic Resonance Imaging
Lung

Keywords

  • Apparent diffusion coefficient
  • COPD
  • Emphysema
  • HyperpolarizedXe MRI
  • HyperpolarizedHe MRI

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients : Physiological relevance in older never-and ex-smokers. / Kirby, Miranda; Ouriadov, Alexei; Svenningsen, Sarah; Owrangi, Amir; Wheatley, Andrew; Etemad-Rezai, Roya; Santyr, Giles E.; McCormack, David G.; Parraga, Grace.

In: Physiological Reports, Vol. 2, No. 7, e12068, 01.01.2014.

Research output: Contribution to journalArticle

Kirby, M, Ouriadov, A, Svenningsen, S, Owrangi, A, Wheatley, A, Etemad-Rezai, R, Santyr, GE, McCormack, DG & Parraga, G 2014, 'Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients: Physiological relevance in older never-and ex-smokers', Physiological Reports, vol. 2, no. 7, e12068. https://doi.org/10.14814/phy2.12068
Kirby, Miranda ; Ouriadov, Alexei ; Svenningsen, Sarah ; Owrangi, Amir ; Wheatley, Andrew ; Etemad-Rezai, Roya ; Santyr, Giles E. ; McCormack, David G. ; Parraga, Grace. / Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients : Physiological relevance in older never-and ex-smokers. In: Physiological Reports. 2014 ; Vol. 2, No. 7.
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abstract = "Noble gas pulmonary magnetic resonance imaging (MRI) is transitioning away from3He to129Xe gas, but the physiological/clinical relevance of129Xe apparent diffusion coefficient (ADC) parenchyma measurements is not well understood. Therefore, our objective was to generate129Xe MRI ADC for comparison with3He ADC and with well-established measurements of alveolar structure and function in older never-smokers and ex-smokers with chronic obstructive pulmonary disease (COPD). In four never-smokers and 10 COPD ex-smokers,3He (b = 1.6 sec/cm2) and129Xe (b = 12, 20, and 30 sec/ cm2) ADC, computed tomography (CT) density-threshold measurements, and the diffusing capacity for carbon monoxide (DLCO) were measured. To understand regional differences, the anterior-posterior (APG) and superior-inferior (ΔSI) ADC differences were evaluated. Compared to never-smokers, COPD ex-smokers showed greater3He ADC (P = 0.006),129Xe ADCb12 (P = 0.006), and ADCb20 (P = 0.006), but not for ADCb30 (P > 0.05). Never-smokers and COPD ex-smokers had significantly different APG for3He ADC (P = 0.02),129Xe ADCb12 (P = 0.006), and ADCb20 (P = 0.01), but not for ADCb30 (P > 0.05). ΔSI for never-and ex-smokers was significantly different for3He ADC (P = 0.046), but not for129Xe ADC (P > 0.05). There were strong correlations for DLCO with3He ADC and129Xe ADCb12 (both r = −0.95, P < 0.05); in a multivariate model129Xe ADCb12 was the only significant predictor of DLCO (P = 0.049). For COPD ex-smokers, CT relative area <_950 HU (RA950) correlated with3He ADC (r = 0.90, P = 0.008) and129Xe ADCb12 (r = 0.85, P = 0.03). In conclusion, while129Xe ADCb30 may be appropriate for evaluating subclinical or mild emphysema, in this small group of never-smokers and ex-smokers with moderate-to-severe emphysema,129Xe ADCb12 provided a physiologically appropriate estimate of gas exchange abnormalities and alveolar microstructure.",
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AU - Kirby, Miranda

AU - Ouriadov, Alexei

AU - Svenningsen, Sarah

AU - Owrangi, Amir

AU - Wheatley, Andrew

AU - Etemad-Rezai, Roya

AU - Santyr, Giles E.

AU - McCormack, David G.

AU - Parraga, Grace

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N2 - Noble gas pulmonary magnetic resonance imaging (MRI) is transitioning away from3He to129Xe gas, but the physiological/clinical relevance of129Xe apparent diffusion coefficient (ADC) parenchyma measurements is not well understood. Therefore, our objective was to generate129Xe MRI ADC for comparison with3He ADC and with well-established measurements of alveolar structure and function in older never-smokers and ex-smokers with chronic obstructive pulmonary disease (COPD). In four never-smokers and 10 COPD ex-smokers,3He (b = 1.6 sec/cm2) and129Xe (b = 12, 20, and 30 sec/ cm2) ADC, computed tomography (CT) density-threshold measurements, and the diffusing capacity for carbon monoxide (DLCO) were measured. To understand regional differences, the anterior-posterior (APG) and superior-inferior (ΔSI) ADC differences were evaluated. Compared to never-smokers, COPD ex-smokers showed greater3He ADC (P = 0.006),129Xe ADCb12 (P = 0.006), and ADCb20 (P = 0.006), but not for ADCb30 (P > 0.05). Never-smokers and COPD ex-smokers had significantly different APG for3He ADC (P = 0.02),129Xe ADCb12 (P = 0.006), and ADCb20 (P = 0.01), but not for ADCb30 (P > 0.05). ΔSI for never-and ex-smokers was significantly different for3He ADC (P = 0.046), but not for129Xe ADC (P > 0.05). There were strong correlations for DLCO with3He ADC and129Xe ADCb12 (both r = −0.95, P < 0.05); in a multivariate model129Xe ADCb12 was the only significant predictor of DLCO (P = 0.049). For COPD ex-smokers, CT relative area <_950 HU (RA950) correlated with3He ADC (r = 0.90, P = 0.008) and129Xe ADCb12 (r = 0.85, P = 0.03). In conclusion, while129Xe ADCb30 may be appropriate for evaluating subclinical or mild emphysema, in this small group of never-smokers and ex-smokers with moderate-to-severe emphysema,129Xe ADCb12 provided a physiologically appropriate estimate of gas exchange abnormalities and alveolar microstructure.

AB - Noble gas pulmonary magnetic resonance imaging (MRI) is transitioning away from3He to129Xe gas, but the physiological/clinical relevance of129Xe apparent diffusion coefficient (ADC) parenchyma measurements is not well understood. Therefore, our objective was to generate129Xe MRI ADC for comparison with3He ADC and with well-established measurements of alveolar structure and function in older never-smokers and ex-smokers with chronic obstructive pulmonary disease (COPD). In four never-smokers and 10 COPD ex-smokers,3He (b = 1.6 sec/cm2) and129Xe (b = 12, 20, and 30 sec/ cm2) ADC, computed tomography (CT) density-threshold measurements, and the diffusing capacity for carbon monoxide (DLCO) were measured. To understand regional differences, the anterior-posterior (APG) and superior-inferior (ΔSI) ADC differences were evaluated. Compared to never-smokers, COPD ex-smokers showed greater3He ADC (P = 0.006),129Xe ADCb12 (P = 0.006), and ADCb20 (P = 0.006), but not for ADCb30 (P > 0.05). Never-smokers and COPD ex-smokers had significantly different APG for3He ADC (P = 0.02),129Xe ADCb12 (P = 0.006), and ADCb20 (P = 0.01), but not for ADCb30 (P > 0.05). ΔSI for never-and ex-smokers was significantly different for3He ADC (P = 0.046), but not for129Xe ADC (P > 0.05). There were strong correlations for DLCO with3He ADC and129Xe ADCb12 (both r = −0.95, P < 0.05); in a multivariate model129Xe ADCb12 was the only significant predictor of DLCO (P = 0.049). For COPD ex-smokers, CT relative area <_950 HU (RA950) correlated with3He ADC (r = 0.90, P = 0.008) and129Xe ADCb12 (r = 0.85, P = 0.03). In conclusion, while129Xe ADCb30 may be appropriate for evaluating subclinical or mild emphysema, in this small group of never-smokers and ex-smokers with moderate-to-severe emphysema,129Xe ADCb12 provided a physiologically appropriate estimate of gas exchange abnormalities and alveolar microstructure.

KW - Apparent diffusion coefficient

KW - COPD

KW - Emphysema

KW - HyperpolarizedXe MRI

KW - HyperpolarizedHe MRI

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