Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease

Miranda Kirby, Sarah Svenningsen, Amir Owrangi, Andrew Wheatley, Adam Farag, Alexei Ouriadov, Giles E. Santyr, Roya Etemad-Rezai, Harvey O. Coxson, David G. McCormack, Grace Parraga

Research output: Contribution to journalArticle

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Abstract

Purpose: To quantitatively compare hyperpolarized helium 3 ( 3He) and xenon 129 ( 129Xe) magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD) and to evaluate the correlations between 3He and 129Xe MR imaging measurements and those from spirometry and plethysmography. Materials and Methods: This study was approved by an ethics board and compliant with HIPAA. Written informed consent was obtained from all subjects. Eight healthy volunteers and 10 patients with COPD underwent MR imaging, spirometry, and plethysmography. Ventilation defect percentages (VDPs) at 3He and 129Xe imaging were obtained by using semiautomated segmentation. Apparent diffusion coefficients (ADCs) were calculated from 3He (b = 1.6 sec/cm 2) and 129Xe (b = 12 sec/cm 2) diffusion-weighted images. VDPs at hyperpolarized 3He and 129Xe imaging were compared with a two-tailed Wilcoxon signed rank test and analysis of variance; Pearson correlation coefficients were used to evaluate the relationships among measurements. Results: 129Xe VDP was significantly greater than 3He VDP for patients with COPD (P < .0001) but not for healthy volunteers (P = .35), although 3He and 129Xe VDPs showed a significant correlation for all subjects (r = 0.91, P < .0001). The forced expiratory volume in 1 second (FEV 1) showed a similar and significant correlation with 3He VDP (r = -0.84, P < .0001) and 129Xe VDP (r = -0.89, P < .0001), although the correlation between the FEV 1/forced vital capacity (FVC) ratio and 129Xe VDP (r = -0.95, P < .0001) was significantly greater (P = .01) than that for FEV 1/FVC and 3He VDP (r = -0.84, P < .0001). A significant correlation was also observed for 3He and 129Xe ADC (r = 0.97, P < .0001); 129Xe ADC was significantly correlated with diffusing capacity of lung for carbon monoxide (r = -0.79, P = .03) and computed tomographic emphysema measurements (areas with attenuation values in the 15th percentile: r = 20.91, P = .0003; relative areas with attenuation values of less than -950 HU: r = 0.87, P = .001). Conclusion: In patients with COPD, the VDP obtained with hyperpolarized 29Xe MR imaging was significantly greater than that with 3He MR imaging, suggesting incomplete or delayed filling of lung regions that may be related to the different properties of 129Xe gas and physiologic and/or anatomic abnormalities in COPD.

Original languageEnglish (US)
Pages (from-to)600-610
Number of pages11
JournalRadiology
Volume265
Issue number2
DOIs
StatePublished - Nov 1 2012

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Chronic Obstructive Pulmonary Disease
Ventilation
Healthy Volunteers
Magnetic Resonance Imaging
Forced Expiratory Volume
Plethysmography
Spirometry
Vital Capacity
Health Insurance Portability and Accountability Act
Lung Volume Measurements
Pulmonary Ventilation
Helium
Xenon
Emphysema
Carbon Monoxide
Nonparametric Statistics
Informed Consent
Ethics
Analysis of Variance
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease. / Kirby, Miranda; Svenningsen, Sarah; Owrangi, Amir; Wheatley, Andrew; Farag, Adam; Ouriadov, Alexei; Santyr, Giles E.; Etemad-Rezai, Roya; Coxson, Harvey O.; McCormack, David G.; Parraga, Grace.

In: Radiology, Vol. 265, No. 2, 01.11.2012, p. 600-610.

Research output: Contribution to journalArticle

Kirby, M, Svenningsen, S, Owrangi, A, Wheatley, A, Farag, A, Ouriadov, A, Santyr, GE, Etemad-Rezai, R, Coxson, HO, McCormack, DG & Parraga, G 2012, 'Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease', Radiology, vol. 265, no. 2, pp. 600-610. https://doi.org/10.1148/radiol.12120485
Kirby, Miranda ; Svenningsen, Sarah ; Owrangi, Amir ; Wheatley, Andrew ; Farag, Adam ; Ouriadov, Alexei ; Santyr, Giles E. ; Etemad-Rezai, Roya ; Coxson, Harvey O. ; McCormack, David G. ; Parraga, Grace. / Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease. In: Radiology. 2012 ; Vol. 265, No. 2. pp. 600-610.
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abstract = "Purpose: To quantitatively compare hyperpolarized helium 3 ( 3He) and xenon 129 ( 129Xe) magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD) and to evaluate the correlations between 3He and 129Xe MR imaging measurements and those from spirometry and plethysmography. Materials and Methods: This study was approved by an ethics board and compliant with HIPAA. Written informed consent was obtained from all subjects. Eight healthy volunteers and 10 patients with COPD underwent MR imaging, spirometry, and plethysmography. Ventilation defect percentages (VDPs) at 3He and 129Xe imaging were obtained by using semiautomated segmentation. Apparent diffusion coefficients (ADCs) were calculated from 3He (b = 1.6 sec/cm 2) and 129Xe (b = 12 sec/cm 2) diffusion-weighted images. VDPs at hyperpolarized 3He and 129Xe imaging were compared with a two-tailed Wilcoxon signed rank test and analysis of variance; Pearson correlation coefficients were used to evaluate the relationships among measurements. Results: 129Xe VDP was significantly greater than 3He VDP for patients with COPD (P < .0001) but not for healthy volunteers (P = .35), although 3He and 129Xe VDPs showed a significant correlation for all subjects (r = 0.91, P < .0001). The forced expiratory volume in 1 second (FEV 1) showed a similar and significant correlation with 3He VDP (r = -0.84, P < .0001) and 129Xe VDP (r = -0.89, P < .0001), although the correlation between the FEV 1/forced vital capacity (FVC) ratio and 129Xe VDP (r = -0.95, P < .0001) was significantly greater (P = .01) than that for FEV 1/FVC and 3He VDP (r = -0.84, P < .0001). A significant correlation was also observed for 3He and 129Xe ADC (r = 0.97, P < .0001); 129Xe ADC was significantly correlated with diffusing capacity of lung for carbon monoxide (r = -0.79, P = .03) and computed tomographic emphysema measurements (areas with attenuation values in the 15th percentile: r = 20.91, P = .0003; relative areas with attenuation values of less than -950 HU: r = 0.87, P = .001). Conclusion: In patients with COPD, the VDP obtained with hyperpolarized 29Xe MR imaging was significantly greater than that with 3He MR imaging, suggesting incomplete or delayed filling of lung regions that may be related to the different properties of 129Xe gas and physiologic and/or anatomic abnormalities in COPD.",
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TY - JOUR

T1 - Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease

AU - Kirby, Miranda

AU - Svenningsen, Sarah

AU - Owrangi, Amir

AU - Wheatley, Andrew

AU - Farag, Adam

AU - Ouriadov, Alexei

AU - Santyr, Giles E.

AU - Etemad-Rezai, Roya

AU - Coxson, Harvey O.

AU - McCormack, David G.

AU - Parraga, Grace

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Purpose: To quantitatively compare hyperpolarized helium 3 ( 3He) and xenon 129 ( 129Xe) magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD) and to evaluate the correlations between 3He and 129Xe MR imaging measurements and those from spirometry and plethysmography. Materials and Methods: This study was approved by an ethics board and compliant with HIPAA. Written informed consent was obtained from all subjects. Eight healthy volunteers and 10 patients with COPD underwent MR imaging, spirometry, and plethysmography. Ventilation defect percentages (VDPs) at 3He and 129Xe imaging were obtained by using semiautomated segmentation. Apparent diffusion coefficients (ADCs) were calculated from 3He (b = 1.6 sec/cm 2) and 129Xe (b = 12 sec/cm 2) diffusion-weighted images. VDPs at hyperpolarized 3He and 129Xe imaging were compared with a two-tailed Wilcoxon signed rank test and analysis of variance; Pearson correlation coefficients were used to evaluate the relationships among measurements. Results: 129Xe VDP was significantly greater than 3He VDP for patients with COPD (P < .0001) but not for healthy volunteers (P = .35), although 3He and 129Xe VDPs showed a significant correlation for all subjects (r = 0.91, P < .0001). The forced expiratory volume in 1 second (FEV 1) showed a similar and significant correlation with 3He VDP (r = -0.84, P < .0001) and 129Xe VDP (r = -0.89, P < .0001), although the correlation between the FEV 1/forced vital capacity (FVC) ratio and 129Xe VDP (r = -0.95, P < .0001) was significantly greater (P = .01) than that for FEV 1/FVC and 3He VDP (r = -0.84, P < .0001). A significant correlation was also observed for 3He and 129Xe ADC (r = 0.97, P < .0001); 129Xe ADC was significantly correlated with diffusing capacity of lung for carbon monoxide (r = -0.79, P = .03) and computed tomographic emphysema measurements (areas with attenuation values in the 15th percentile: r = 20.91, P = .0003; relative areas with attenuation values of less than -950 HU: r = 0.87, P = .001). Conclusion: In patients with COPD, the VDP obtained with hyperpolarized 29Xe MR imaging was significantly greater than that with 3He MR imaging, suggesting incomplete or delayed filling of lung regions that may be related to the different properties of 129Xe gas and physiologic and/or anatomic abnormalities in COPD.

AB - Purpose: To quantitatively compare hyperpolarized helium 3 ( 3He) and xenon 129 ( 129Xe) magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD) and to evaluate the correlations between 3He and 129Xe MR imaging measurements and those from spirometry and plethysmography. Materials and Methods: This study was approved by an ethics board and compliant with HIPAA. Written informed consent was obtained from all subjects. Eight healthy volunteers and 10 patients with COPD underwent MR imaging, spirometry, and plethysmography. Ventilation defect percentages (VDPs) at 3He and 129Xe imaging were obtained by using semiautomated segmentation. Apparent diffusion coefficients (ADCs) were calculated from 3He (b = 1.6 sec/cm 2) and 129Xe (b = 12 sec/cm 2) diffusion-weighted images. VDPs at hyperpolarized 3He and 129Xe imaging were compared with a two-tailed Wilcoxon signed rank test and analysis of variance; Pearson correlation coefficients were used to evaluate the relationships among measurements. Results: 129Xe VDP was significantly greater than 3He VDP for patients with COPD (P < .0001) but not for healthy volunteers (P = .35), although 3He and 129Xe VDPs showed a significant correlation for all subjects (r = 0.91, P < .0001). The forced expiratory volume in 1 second (FEV 1) showed a similar and significant correlation with 3He VDP (r = -0.84, P < .0001) and 129Xe VDP (r = -0.89, P < .0001), although the correlation between the FEV 1/forced vital capacity (FVC) ratio and 129Xe VDP (r = -0.95, P < .0001) was significantly greater (P = .01) than that for FEV 1/FVC and 3He VDP (r = -0.84, P < .0001). A significant correlation was also observed for 3He and 129Xe ADC (r = 0.97, P < .0001); 129Xe ADC was significantly correlated with diffusing capacity of lung for carbon monoxide (r = -0.79, P = .03) and computed tomographic emphysema measurements (areas with attenuation values in the 15th percentile: r = 20.91, P = .0003; relative areas with attenuation values of less than -950 HU: r = 0.87, P = .001). Conclusion: In patients with COPD, the VDP obtained with hyperpolarized 29Xe MR imaging was significantly greater than that with 3He MR imaging, suggesting incomplete or delayed filling of lung regions that may be related to the different properties of 129Xe gas and physiologic and/or anatomic abnormalities in COPD.

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