Hyperpolarized 89Y complexes as pH sensitive NMR probes

Ashish K. Jindal, Matthew E. Merritt, Eul Hyun Suh, Craig R. Malloy, A. Dean Sherry, Zoltán Kovács

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

(Chemical Presented)Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T1 decay of magnetization. Due to its long T1, the hyperpolarized 89Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the 89Y chemical shift dependence upon pH for two hyperpolarized 89Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.

Original languageEnglish (US)
Pages (from-to)1784-1785
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number6
DOIs
StatePublished - 2010

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Spectrum Analysis
Nuclear magnetic resonance
Spectroscopy
Imaging techniques
Chemical shift
Magnetic resonance imaging
Magnetization
Experiments

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Hyperpolarized 89Y complexes as pH sensitive NMR probes. / Jindal, Ashish K.; Merritt, Matthew E.; Suh, Eul Hyun; Malloy, Craig R.; Sherry, A. Dean; Kovács, Zoltán.

In: Journal of the American Chemical Society, Vol. 132, No. 6, 2010, p. 1784-1785.

Research output: Contribution to journalArticle

Jindal, Ashish K. ; Merritt, Matthew E. ; Suh, Eul Hyun ; Malloy, Craig R. ; Sherry, A. Dean ; Kovács, Zoltán. / Hyperpolarized 89Y complexes as pH sensitive NMR probes. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 6. pp. 1784-1785.
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