Hyperpolarized 89Y complexes as pH sensitive NMR probes

Ashish K. Jindal, Matthew E. Merritt, Eul Hyun Suh, Craig R. Malloy, A. Dean Sherry, Zoltán Kovács

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

(Chemical Presented)Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T1 decay of magnetization. Due to its long T1, the hyperpolarized 89Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the 89Y chemical shift dependence upon pH for two hyperpolarized 89Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.

Original languageEnglish (US)
Pages (from-to)1784-1785
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number6
DOIs
StatePublished - Mar 1 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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