Hyperpolarized 89Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance

Matthew E. Merritt, Crystal Harrison, Zoltan Kovacs, Preeti Kshirsagar, Craig R. Malloy, A. Dean Sherry

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Hyperpolarization of 89YCl3 and three 89Y-complexes was achieved by dynamic nuclear polarization of aqueous samples. The long T1s of 89Y make its application as an NMR imaging probe extremely promising. In addition, the wide chemical shift range for various chelates of 89Y means that agents sensitive to their biological/chemical milieu could serve as exquisite sensors of important biological events.

Original languageEnglish (US)
Pages (from-to)12942-12943
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number43
DOIs
StatePublished - Oct 31 2007

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Chemical shift
Biological systems
Magnetic resonance
Metal ions
Magnetic Resonance Spectroscopy
Metals
Magnetic Resonance Imaging
Ions
Polarization
Imaging techniques
Sensors

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Hyperpolarized 89Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance. / Merritt, Matthew E.; Harrison, Crystal; Kovacs, Zoltan; Kshirsagar, Preeti; Malloy, Craig R.; Sherry, A. Dean.

In: Journal of the American Chemical Society, Vol. 129, No. 43, 31.10.2007, p. 12942-12943.

Research output: Contribution to journalArticle

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