Hyperspectral imaging of neoplastic progression in a mouse model of oral carcinogenesis

Guolan Lu, Xulei Qin, Dongsheng Wang, Susan Muller, Hongzheng Zhang, Amy Chen, Zhuo Georgia Chen, Baowei Fei

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Citations (Scopus)

Abstract

Hyperspectral imaging (HSI) is an emerging modality for medical applications and holds great potential for noninvasive early detection of cancer. It has been reported that early cancer detection can improve the survival and quality of life of head and neck cancer patients. In this paper, we explored the possibility of differentiating between premalignant lesions and healthy tongue tissue using hyperspectral imaging in a chemical induced oral cancer animal model. We proposed a novel classification algorithm for cancer detection using hyperspectral images. The method detected the dysplastic tissue with an average area under the curve (AUC) of 0.89. The hyperspectral imaging and classification technique may provide a new tool for oral cancer detection.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor Gimi, Andrzej Krol
PublisherSPIE
ISBN (Electronic)9781510600232
DOIs
StatePublished - Jan 1 2016
Externally publishedYes
EventMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, United States
Duration: Mar 1 2016Mar 3 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9788
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego
Period3/1/163/3/16

Fingerprint

Mouth Neoplasms
Early Detection of Cancer
progressions
mice
Carcinogenesis
cancer
Head and Neck Neoplasms
Tongue
Tissue
Area Under Curve
Animal Models
Quality of Life
Medical applications
Survival
Animals
Neoplasms
animal models
tongue
imaging techniques
lesions

Keywords

  • 4NQO-induced oral cancer
  • Early cancer detection
  • Hyperspectral imaging
  • Image classification
  • Random forest
  • Superpixel

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Lu, G., Qin, X., Wang, D., Muller, S., Zhang, H., Chen, A., ... Fei, B. (2016). Hyperspectral imaging of neoplastic progression in a mouse model of oral carcinogenesis. In B. Gimi, & A. Krol (Eds.), Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging [978812] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9788). SPIE. https://doi.org/10.1117/12.2216553

Hyperspectral imaging of neoplastic progression in a mouse model of oral carcinogenesis. / Lu, Guolan; Qin, Xulei; Wang, Dongsheng; Muller, Susan; Zhang, Hongzheng; Chen, Amy; Chen, Zhuo Georgia; Fei, Baowei.

Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. ed. / Barjor Gimi; Andrzej Krol. SPIE, 2016. 978812 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9788).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lu, G, Qin, X, Wang, D, Muller, S, Zhang, H, Chen, A, Chen, ZG & Fei, B 2016, Hyperspectral imaging of neoplastic progression in a mouse model of oral carcinogenesis. in B Gimi & A Krol (eds), Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging., 978812, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9788, SPIE, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, United States, 3/1/16. https://doi.org/10.1117/12.2216553
Lu G, Qin X, Wang D, Muller S, Zhang H, Chen A et al. Hyperspectral imaging of neoplastic progression in a mouse model of oral carcinogenesis. In Gimi B, Krol A, editors, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE. 2016. 978812. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2216553
Lu, Guolan ; Qin, Xulei ; Wang, Dongsheng ; Muller, Susan ; Zhang, Hongzheng ; Chen, Amy ; Chen, Zhuo Georgia ; Fei, Baowei. / Hyperspectral imaging of neoplastic progression in a mouse model of oral carcinogenesis. Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. editor / Barjor Gimi ; Andrzej Krol. SPIE, 2016. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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