Hypertension-induced vascular remodeling contributes to reduced cerebral perfusion and the development of spontaneous stroke in aged SHRSP rats

Erica C. Henning, Steven Warach, Maria Spatz

Research output: Contribution to journalArticle

30 Scopus citations


Stroke in spontaneously-hypertensive, stroke-prone (SHRSP) rats is of particular interest because the pathogenesis is believed to be similar to that in the clinical setting. In this study, we employed multi-modal MRIASL, DWI, T"2, GRE, T"1 (prepost contrast)to investigate the natural history of spontaneous cerebral infarction and the specific role of cerebral perfusion in disease development. Twelve female SHRSP rats (age: ∼1 year) were imaged within 1 to 3 days of symptom onset. The distribution of ischemic lesions was the following: 28.1 visual, 21.9 striatal, 18.8 motorsensory, 12.5 thalamic, 12.5 auditory, 3.1 frontalprelimbic, and 3.1 multiple areas. Ischemic lesions had significantly reduced blood flow in comparison with healthy tissue. Ischemic lesions were characterized by hyperplastic, thrombosed, and compressed vessels. These findings suggest that ischemic lesion development is related to hypertension-induced vascular remodeling and persistent hypoperfusion. This model should be useful for studying the relationship between chronic hypertension and subsequent stroke, both in terms of primary and secondary prevention.

Original languageEnglish (US)
Pages (from-to)827-836
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number4
StatePublished - Apr 1 2010



  • ASL
  • Hypertension
  • MRI
  • Perfusion
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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