Hypertension: The missing WNKs

Hashem A. Dbouk; Chou Long Huang; Melanie H. Cobb

doi:10.1152/ajprenal.00358.2015

Hypertension: The missing WNKs

Hashem A. Dbouk, Chou Long Huang, Melanie H. Cobb

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

The With no Lysine [K] (WNK) family of enzymes are central in the regulation of blood pressure. WNKs have been implicated in hereditary hypertension disorders, mainly through control of the activity and levels of ion cotransporters and channels. Actions of WNKs in the kidney have been heavily investigated, and recent studies have provided insight into not only the regulation of these enzymes but also how mutations in WNKs and their interacting partners contribute to hypertensive disorders. Defining the roles of WNKs in the cardiovascular system will provide clues about additional mechanisms by which WNKs can regulate blood pressure. This review summarizes recent developments in the regulation of the WNK signaling cascade and its role in regulation of blood pressure.

Original language	English (US)
Pages (from-to)	F16-F27
Journal	American Journal of Physiology - Renal Physiology
Volume	311
Issue number	1
DOIs	https://doi.org/10.1152/ajprenal.00358.2015
State	Published - Jul 1 2016

Keywords

Cardiovascular
Hypertension
WNK

ASJC Scopus subject areas

Physiology
Urology

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10.1152/ajprenal.00358.2015

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Hypertension: The missing WNKs

Abstract

Keywords

ASJC Scopus subject areas

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