Hypertension

The missing WNKs

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The With no Lysine [K] (WNK) family of enzymes are central in the regulation of blood pressure. WNKs have been implicated in hereditary hypertension disorders, mainly through control of the activity and levels of ion cotransporters and channels. Actions of WNKs in the kidney have been heavily investigated, and recent studies have provided insight into not only the regulation of these enzymes but also how mutations in WNKs and their interacting partners contribute to hypertensive disorders. Defining the roles of WNKs in the cardiovascular system will provide clues about additional mechanisms by which WNKs can regulate blood pressure. This review summarizes recent developments in the regulation of the WNK signaling cascade and its role in regulation of blood pressure.

Original languageEnglish (US)
Pages (from-to)F16-F27
JournalAmerican Journal of Physiology - Renal Physiology
Volume311
Issue number1
DOIs
StatePublished - Jul 1 2016

Fingerprint

Blood Pressure
Hypertension
Enzymes
Cardiovascular System
Ion Channels
Lysine
Kidney
Mutation

Keywords

  • Cardiovascular
  • Hypertension
  • WNK

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Hypertension : The missing WNKs. / Dbouk, Hashem A.; Huang, Chou Long; Cobb, Melanie H.

In: American Journal of Physiology - Renal Physiology, Vol. 311, No. 1, 01.07.2016, p. F16-F27.

Research output: Contribution to journalReview article

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