@article{88b5d1ddafdb406dbe72d38ad32bd579,
title = "Hypertonic saline-dextran solutions for the prehospital management of traumatic hypotension",
abstract = "We report the results of the first clinical study on the use of a Hypertonic saline-dextran solution for the prehospital management of hypotensive victims of penetrating trauma. During a 4-month period, 48 trauma patients with penetrating injuries and a prehospital systolic blood pressure of 90 mm Hg or less were infused in-field with 250 ml of either a hypertonic saline-dextran solution or the crystalloid plasmalyte A. There were no complications associated with the infusion of the hypertonic saline-dextran solution, and execution of the protocol by paramedic personnel was both safe and uniformly successful. The potential impact of this solution on medical care and the results of this feasibility study justify the initiation of a larger prospective, randomized clinical trial on the efficacy of this solution in the prehospital setting.",
author = "Maningas, {Peter A.} and Mattox, {Kenneth L.} and Pepe, {Paul E.} and Jones, {Robert L.} and Feliciano, {David V.} and Burch, {Jon M.}",
note = "Funding Information: From the Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, California; the Departments of Surgery, Anesthesiology, and Medicine, Baylor College of Medicine; and the Houston Fire Department Emergency Medical Services Division, Houston, Texas. Supported in part by a grant from Pharmacia AB, Uppsala, Sweden. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. Requests for reprints should be addressed to Peter A. Maningas, MD, Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, California 94129-6800. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1989",
month = may,
doi = "10.1016/0002-9610(89)90654-5",
language = "English (US)",
volume = "157",
pages = "528--533",
journal = "The American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "5",
}