Hypertriglyceridemia

Examining its role in coronary heart disease

Research output: Contribution to journalArticle

Abstract

If triglyceride-rich very-low-density lipoproteins (VLDLs) are a vehicle for transporting cholesterol into the arterial wall, they can be equated to low-density lipoproteins (LDLs) in estimating CHD risk and setting targets for therapy. Furthermore, the fate of cholesterol-rich VLDL (VLDL remnants) is similar to that of LDL; that is, both are removed from the circulation via LDL receptors. Thus, combining VLDL and LDL into a common category of atherogenic lipoproteins provides a rational framework for treatment of hypercholesterolemic patients with hypertriglyceridemia. A hydroxymethylglutaryl coenzyme A reductase inhibitor may be the best choice for treatment when both triglyceride and cholesterol levels are elevated, because these agents cause the greatest reduction in VLDL and LDL cholesterol levels. When hypertriglyceridemia is severe, a fibric acid or nicotinic acid is preferable, because these agents are more effective for lowering triglyceride levels and hence for reducing risk for acute pancreatitis.

Original languageEnglish (US)
Pages (from-to)201-202+207+210
JournalPostgraduate Medicine
Volume90
Issue number5
StatePublished - 1991

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VLDL Lipoproteins
Hypertriglyceridemia
LDL Lipoproteins
Coronary Disease
Triglycerides
Hydroxymethylglutaryl-CoA Reductase Inhibitors
VLDL Cholesterol
LDL Receptors
Niacin
Hypercholesterolemia
Pancreatitis
LDL Cholesterol
Lipoproteins
Oxidoreductases
Therapeutics
Cholesterol

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hypertriglyceridemia : Examining its role in coronary heart disease. / Grundy, Scott M.

In: Postgraduate Medicine, Vol. 90, No. 5, 1991, p. 201-202+207+210.

Research output: Contribution to journalArticle

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