Hypertrophic olivary degeneration: Case series and review of literature

Shyam Sabat, Neil Mannering, Amit Agarwal

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Hypertrophic Olivary Degeneration (HOD) is a rare neurological condition caused by trans-synaptic degeneration in the brainstem and cerebellum, resulting in varied clinical symptoms, classical being palatal tremors, along with characteristic imaging presentation. Large number of pathologic lesions can cause this condition, ranging from ischemic stroke to neoplasm. The most common conditions include hemorrhage, vascular malformations and infarct. Magnetic resonance scan (MRI) is the imaging modality of choice which shows signal changes with hypertrophy of the inferior olivary nucleus, as well as the primary underlying pathology. Through this pictorial essay, we present the imaging and clinical findings in a number of patients with HOD secondary to varied causes and explain the mechanism behind the changes.

Original languageEnglish (US)
Pages (from-to)180-186
Number of pages7
JournalJournal of the Neurological Sciences
StatePublished - Nov 15 2016


  • Degeneration
  • Hypertrophic
  • MRI
  • Olivary

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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