Hypertrophic olivary degeneration: Case series and review of literature

Shyam Sabat, Neil Mannering, Amit Agarwal

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Hypertrophic Olivary Degeneration (HOD) is a rare neurological condition caused by trans-synaptic degeneration in the brainstem and cerebellum, resulting in varied clinical symptoms, classical being palatal tremors, along with characteristic imaging presentation. Large number of pathologic lesions can cause this condition, ranging from ischemic stroke to neoplasm. The most common conditions include hemorrhage, vascular malformations and infarct. Magnetic resonance scan (MRI) is the imaging modality of choice which shows signal changes with hypertrophy of the inferior olivary nucleus, as well as the primary underlying pathology. Through this pictorial essay, we present the imaging and clinical findings in a number of patients with HOD secondary to varied causes and explain the mechanism behind the changes.

Original languageEnglish (US)
Pages (from-to)180-186
Number of pages7
JournalJournal of the Neurological Sciences
Volume370
DOIs
StatePublished - Nov 15 2016

Fingerprint

Retrograde Degeneration
Olivary Nucleus
Vascular Malformations
Tremor
Cerebellum
Hypertrophy
Brain Stem
Magnetic Resonance Spectroscopy
Stroke
Magnetic Resonance Imaging
Pathology
Hemorrhage
Neoplasms

Keywords

  • Degeneration
  • Hypertrophic
  • MRI
  • Olivary

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Hypertrophic olivary degeneration : Case series and review of literature. / Sabat, Shyam; Mannering, Neil; Agarwal, Amit.

In: Journal of the Neurological Sciences, Vol. 370, 15.11.2016, p. 180-186.

Research output: Contribution to journalReview article

@article{b736662f03cd41fe8c579f4dfda3e8dd,
title = "Hypertrophic olivary degeneration: Case series and review of literature",
abstract = "Hypertrophic Olivary Degeneration (HOD) is a rare neurological condition caused by trans-synaptic degeneration in the brainstem and cerebellum, resulting in varied clinical symptoms, classical being palatal tremors, along with characteristic imaging presentation. Large number of pathologic lesions can cause this condition, ranging from ischemic stroke to neoplasm. The most common conditions include hemorrhage, vascular malformations and infarct. Magnetic resonance scan (MRI) is the imaging modality of choice which shows signal changes with hypertrophy of the inferior olivary nucleus, as well as the primary underlying pathology. Through this pictorial essay, we present the imaging and clinical findings in a number of patients with HOD secondary to varied causes and explain the mechanism behind the changes.",
keywords = "Degeneration, Hypertrophic, MRI, Olivary",
author = "Shyam Sabat and Neil Mannering and Amit Agarwal",
year = "2016",
month = "11",
day = "15",
doi = "10.1016/j.jns.2016.09.055",
language = "English (US)",
volume = "370",
pages = "180--186",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Hypertrophic olivary degeneration

T2 - Case series and review of literature

AU - Sabat, Shyam

AU - Mannering, Neil

AU - Agarwal, Amit

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Hypertrophic Olivary Degeneration (HOD) is a rare neurological condition caused by trans-synaptic degeneration in the brainstem and cerebellum, resulting in varied clinical symptoms, classical being palatal tremors, along with characteristic imaging presentation. Large number of pathologic lesions can cause this condition, ranging from ischemic stroke to neoplasm. The most common conditions include hemorrhage, vascular malformations and infarct. Magnetic resonance scan (MRI) is the imaging modality of choice which shows signal changes with hypertrophy of the inferior olivary nucleus, as well as the primary underlying pathology. Through this pictorial essay, we present the imaging and clinical findings in a number of patients with HOD secondary to varied causes and explain the mechanism behind the changes.

AB - Hypertrophic Olivary Degeneration (HOD) is a rare neurological condition caused by trans-synaptic degeneration in the brainstem and cerebellum, resulting in varied clinical symptoms, classical being palatal tremors, along with characteristic imaging presentation. Large number of pathologic lesions can cause this condition, ranging from ischemic stroke to neoplasm. The most common conditions include hemorrhage, vascular malformations and infarct. Magnetic resonance scan (MRI) is the imaging modality of choice which shows signal changes with hypertrophy of the inferior olivary nucleus, as well as the primary underlying pathology. Through this pictorial essay, we present the imaging and clinical findings in a number of patients with HOD secondary to varied causes and explain the mechanism behind the changes.

KW - Degeneration

KW - Hypertrophic

KW - MRI

KW - Olivary

UR - http://www.scopus.com/inward/record.url?scp=84989172777&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989172777&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2016.09.055

DO - 10.1016/j.jns.2016.09.055

M3 - Review article

C2 - 27772756

AN - SCOPUS:84989172777

VL - 370

SP - 180

EP - 186

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

ER -