Hypertrophy of the Heart: A New Therapeutic Target?

Norbert Frey, Hugo A. Katus, Eric N Olson, Joseph A Hill

Research output: Contribution to journalReview article

575 Scopus citations

Abstract

Recent studies call into question the necessity of hypertrophic growth of the heart as a "compensatory" response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling pathways that hold promise as potential targets for therapeutic intervention. We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy.

Original languageEnglish (US)
Pages (from-to)1580-1589
Number of pages10
JournalCirculation
Volume109
Issue number13
DOIs
StatePublished - Apr 6 2004

Keywords

  • Heart failure
  • Hypertrophy
  • Signal transduction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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