Hyperuricemia and risk of stroke: A systematic review and meta-analysis

Young Kim Seo, James P. Guevara, Mi Kim Kyoung, K. Choi Hyon, Daniel F. Heitjan, Daniel A. Albert

Research output: Contribution to journalReview article

273 Citations (Scopus)

Abstract

Objective. To assess the association between hyperuricemia and risk of stroke incidence and mortality because hyperuricemia is hypothesized to be a risk factor for stroke and other cardiovascular disease, but, to date, results from observational studies are conflicting. Methods. A systematic review and meta-analysis were conducted. Studies were identified by searching major electronic databases using the Medical Subject Headings and keywords without restriction in languages. Prospective cohort studies were included only if they contained data on stroke incidences or mortalities related to serum uric acid levels in adults. Pooled risk ratios (RRs) for the association of stroke incidence and mortality with serum uric acid levels were calculated. Results. A total of 16 studies including 238,449 adults were eligible and abstracted. Hyperuricemia was associated with a significantly higher risk of both stroke incidence (6 studies; RR 1.41, 95% confidence interval [95% CI] 1.05, 1.76) and mortality (6 studies; RR 1.36, 95% CI 1.03, 1.69) in our meta-analyses of unadjusted study estimates. Subgroup analyses of studies adjusting for known risk factors such as age, hypertension, diabetes mellitus, and cholesterol still showed that hyperuricemia was significantly associated with both stroke incidence (4 studies; RR 1.47, 95% CI 1.19, 1.76) and mortality (6 studies; RR 1.26, 95% CI 1.12, 1.39). The pooled estimate of multivariate RRs did not differ significantly by sex. Conclusion. Hyperuricemia may modestly increase the risks of both stroke incidence and mortality. Future research is needed to determine whether lowering uric acid level has any beneficial effects on stroke.

Original languageEnglish (US)
Pages (from-to)885-892
Number of pages8
JournalArthritis Care and Research
Volume61
Issue number7
DOIs
StatePublished - Jul 15 2009

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Hyperuricemia
Meta-Analysis
Stroke
Odds Ratio
Mortality
Uric Acid
Confidence Intervals
Cohort Studies
Incidence
Medical Subject Headings
Serum
Observational Studies
Diabetes Mellitus
Cardiovascular Diseases
Language
Cholesterol
Databases
Prospective Studies
Hypertension

ASJC Scopus subject areas

  • Rheumatology

Cite this

Seo, Y. K., Guevara, J. P., Kyoung, M. K., Hyon, K. C., Heitjan, D. F., & Albert, D. A. (2009). Hyperuricemia and risk of stroke: A systematic review and meta-analysis. Arthritis Care and Research, 61(7), 885-892. https://doi.org/10.1002/art.24612

Hyperuricemia and risk of stroke : A systematic review and meta-analysis. / Seo, Young Kim; Guevara, James P.; Kyoung, Mi Kim; Hyon, K. Choi; Heitjan, Daniel F.; Albert, Daniel A.

In: Arthritis Care and Research, Vol. 61, No. 7, 15.07.2009, p. 885-892.

Research output: Contribution to journalReview article

Seo, YK, Guevara, JP, Kyoung, MK, Hyon, KC, Heitjan, DF & Albert, DA 2009, 'Hyperuricemia and risk of stroke: A systematic review and meta-analysis', Arthritis Care and Research, vol. 61, no. 7, pp. 885-892. https://doi.org/10.1002/art.24612
Seo, Young Kim ; Guevara, James P. ; Kyoung, Mi Kim ; Hyon, K. Choi ; Heitjan, Daniel F. ; Albert, Daniel A. / Hyperuricemia and risk of stroke : A systematic review and meta-analysis. In: Arthritis Care and Research. 2009 ; Vol. 61, No. 7. pp. 885-892.
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