Hyperventilation with He-O2 breathing is not decreased by superimposed external resistance

Tony G. Babb, Darren S. DeLorey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study was to determine the effect of imposed external resistance on the ventilatory response to He-O2 breathing during peak exercise. To accomplish this purpose, separate inspiratory and expiratory external resistances were applied to offset for the decrease in intrapulmonary airway resistance with He-O2 breathing. Seven men and three women (69±3 years, mean±S.D.) with normal pulmonary function performed graded cycle ergometry to exhaustion breathing room air, He-O2 (79% He, 21% O2), He-O2 with imposed expiratory resistance, and He-O2 with imposed inspiratory resistance. Ventilation (V̇E), lung mechanics, and PETCO2 were measured during each 1 min increment in work rate and were analyzed by one-way ANOVA for repeated measures at rest, ventilatory threshold (VTh), and peak exercise. In response, V̇E was increased and PETCO2 was decreased at VTh (P<0.01) and peak exercise (P<0.01) whenever breathing He-O2. Thus, V̇E was increased during exercise above VTh with He-O2 breathing regardless of increases in inspiratory or expiratory external resistance. In conclusion, these data suggest that inspiratory resistive unloading is no more important than expiratory resistive unloading to the increase in V̇E with He-O2 breathing during heavy and peak exercise.

Original languageEnglish (US)
Pages (from-to)139-151
Number of pages13
JournalRespiratory Physiology and Neurobiology
Volume133
Issue number1-2
DOIs
StatePublished - Oct 23 2002

Fingerprint

Hyperventilation
Respiration
Ventilation
Exercise
Ergometry
Lung
Airway Resistance
Mechanics
Analysis of Variance
Air

Keywords

  • Exercise, external resistance, He-O
  • Gases, inspired, He-O
  • Mammals, humans
  • Resistance, external
  • Ventilation, He-O breathing

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Hyperventilation with He-O2 breathing is not decreased by superimposed external resistance. / Babb, Tony G.; DeLorey, Darren S.

In: Respiratory Physiology and Neurobiology, Vol. 133, No. 1-2, 23.10.2002, p. 139-151.

Research output: Contribution to journalArticle

@article{32a0a43440204e9795c24aba926b5639,
title = "Hyperventilation with He-O2 breathing is not decreased by superimposed external resistance",
abstract = "The purpose of this study was to determine the effect of imposed external resistance on the ventilatory response to He-O2 breathing during peak exercise. To accomplish this purpose, separate inspiratory and expiratory external resistances were applied to offset for the decrease in intrapulmonary airway resistance with He-O2 breathing. Seven men and three women (69±3 years, mean±S.D.) with normal pulmonary function performed graded cycle ergometry to exhaustion breathing room air, He-O2 (79{\%} He, 21{\%} O2), He-O2 with imposed expiratory resistance, and He-O2 with imposed inspiratory resistance. Ventilation (V̇E), lung mechanics, and PETCO2 were measured during each 1 min increment in work rate and were analyzed by one-way ANOVA for repeated measures at rest, ventilatory threshold (VTh), and peak exercise. In response, V̇E was increased and PETCO2 was decreased at VTh (P<0.01) and peak exercise (P<0.01) whenever breathing He-O2. Thus, V̇E was increased during exercise above VTh with He-O2 breathing regardless of increases in inspiratory or expiratory external resistance. In conclusion, these data suggest that inspiratory resistive unloading is no more important than expiratory resistive unloading to the increase in V̇E with He-O2 breathing during heavy and peak exercise.",
keywords = "Exercise, external resistance, He-O, Gases, inspired, He-O, Mammals, humans, Resistance, external, Ventilation, He-O breathing",
author = "Babb, {Tony G.} and DeLorey, {Darren S.}",
year = "2002",
month = "10",
day = "23",
doi = "10.1016/S1569-9048(02)00165-9",
language = "English (US)",
volume = "133",
pages = "139--151",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Hyperventilation with He-O2 breathing is not decreased by superimposed external resistance

AU - Babb, Tony G.

AU - DeLorey, Darren S.

PY - 2002/10/23

Y1 - 2002/10/23

N2 - The purpose of this study was to determine the effect of imposed external resistance on the ventilatory response to He-O2 breathing during peak exercise. To accomplish this purpose, separate inspiratory and expiratory external resistances were applied to offset for the decrease in intrapulmonary airway resistance with He-O2 breathing. Seven men and three women (69±3 years, mean±S.D.) with normal pulmonary function performed graded cycle ergometry to exhaustion breathing room air, He-O2 (79% He, 21% O2), He-O2 with imposed expiratory resistance, and He-O2 with imposed inspiratory resistance. Ventilation (V̇E), lung mechanics, and PETCO2 were measured during each 1 min increment in work rate and were analyzed by one-way ANOVA for repeated measures at rest, ventilatory threshold (VTh), and peak exercise. In response, V̇E was increased and PETCO2 was decreased at VTh (P<0.01) and peak exercise (P<0.01) whenever breathing He-O2. Thus, V̇E was increased during exercise above VTh with He-O2 breathing regardless of increases in inspiratory or expiratory external resistance. In conclusion, these data suggest that inspiratory resistive unloading is no more important than expiratory resistive unloading to the increase in V̇E with He-O2 breathing during heavy and peak exercise.

AB - The purpose of this study was to determine the effect of imposed external resistance on the ventilatory response to He-O2 breathing during peak exercise. To accomplish this purpose, separate inspiratory and expiratory external resistances were applied to offset for the decrease in intrapulmonary airway resistance with He-O2 breathing. Seven men and three women (69±3 years, mean±S.D.) with normal pulmonary function performed graded cycle ergometry to exhaustion breathing room air, He-O2 (79% He, 21% O2), He-O2 with imposed expiratory resistance, and He-O2 with imposed inspiratory resistance. Ventilation (V̇E), lung mechanics, and PETCO2 were measured during each 1 min increment in work rate and were analyzed by one-way ANOVA for repeated measures at rest, ventilatory threshold (VTh), and peak exercise. In response, V̇E was increased and PETCO2 was decreased at VTh (P<0.01) and peak exercise (P<0.01) whenever breathing He-O2. Thus, V̇E was increased during exercise above VTh with He-O2 breathing regardless of increases in inspiratory or expiratory external resistance. In conclusion, these data suggest that inspiratory resistive unloading is no more important than expiratory resistive unloading to the increase in V̇E with He-O2 breathing during heavy and peak exercise.

KW - Exercise, external resistance, He-O

KW - Gases, inspired, He-O

KW - Mammals, humans

KW - Resistance, external

KW - Ventilation, He-O breathing

UR - http://www.scopus.com/inward/record.url?scp=0037163847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037163847&partnerID=8YFLogxK

U2 - 10.1016/S1569-9048(02)00165-9

DO - 10.1016/S1569-9048(02)00165-9

M3 - Article

C2 - 12385739

AN - SCOPUS:0037163847

VL - 133

SP - 139

EP - 151

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 1-2

ER -