Hypokalemic Nephropathy — A Clue to Cystogenesis?

R. J. Alpern, R. D. Toto

Research output: Contribution to journalEditorialpeer-review

32 Scopus citations


Potassium deficiency has long attracted the attention of both clinicians and physiologists because of its numerous effects on renal function. Since potassium is the most prevalent intracellular cation, it is not surprising that its deficiency results in marked alterations in cell structure and function. The most common abnormality of renal function is a concentrating defect, due to decreased solute concentration in the medulla and the unresponsiveness of the collecting tubule to vasopressin. This resistance to vasopressin is caused by increased prostaglandin production and the consequent prostaglandin-mediated inhibition of adenylate cyclase activation by vasopressin.1 Potassium deficiency is also associated with increased.

Original languageEnglish (US)
Pages (from-to)398-399
Number of pages2
JournalNew England Journal of Medicine
Issue number6
StatePublished - Feb 8 1990

ASJC Scopus subject areas

  • Medicine(all)


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