Hypophysial portal vessel infusion: In vivo demonstration of LRF, FRF, and PIF in pituitary stalk plasma

I. A. Kamberi, R. S. Mical, J. C. Porter

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Plasma from pituitary stalk blood or plasma from femoral artery blood from one group of rats (donors) was infused (at the rate of 2 μl/min for 30 min) into a hypophysial portal vessel of other rats (recipients). Infusion of stalk plasma from donor animals, which had been given 1.25 μg dopamine hydrochloride via the third ventricle, caused a marked increase in the release of LH and FSH in the recipients but a decrease in the release of prolactin. Infusion of stalk plasma from donors not given dopamine had a slight but statistically insignificant effect on the release of LH, FSH, or prolactin in the recipient animals. Infusion of arterial plasma from both types of donors had no effect on the release of these three hormones. These results are considered to indicate that LRF, FRF, and PIF activities in stalk blood are increased following the administration of dopamine via the third ventricle.

Original languageEnglish (US)
Pages (from-to)1042-1046
Number of pages5
JournalEndocrinology
Volume89
Issue number4
DOIs
StatePublished - Oct 1971

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Hypophysial portal vessel infusion: In vivo demonstration of LRF, FRF, and PIF in pituitary stalk plasma'. Together they form a unique fingerprint.

  • Cite this