Hypothalamic-mediated control of glucose balance in the presence and absence of insulin

Teppei Fujikawa, Roberto Coppari

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Diabetes afflicts hundreds of millions worldwide. People affected by type 1 diabetes mellitus (T1DM; the insulindeficient form of diabetes) or type 2 diabetes mellitus (T2DM; the insulin-resistant form of diabetes) have significantly reduced life expectancy compared to normal individuals. This is due in part to the fact that (despite improvements) current anti-diabetic approaches are suboptimal. Indeed, severe morbidities (e.g.: cardiovascular disease, hypertension) are still too often associated with diabetes. Recent preclinical results indicate that different types of hypothalamic neurons are endowed with the ability to mediate the hyperglycemia-lowering action of the adipocyte-derived hormone leptin in an insulin-dependent and insulin-independent fashion. These results may pave the way for better anti-diabetic approaches and therefore positively impact on life expectancy of diabetic subjects.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalAging
Volume6
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Diabetes
  • Hypothalamus
  • Insulin
  • Leptin

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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