Hypothalamic-pituitary-adrenocortical axis dysregulation in acute temporomandibular disorder and low back pain: A marker for chronicity?

John P. Garofalo; Richard C. Robinson; Robert J. Gatchel

doi:10.1111/j.1751-9861.2007.00003.x

Hypothalamic-pituitary-adrenocortical axis dysregulation in acute temporomandibular disorder and low back pain: A marker for chronicity?

John P. Garofalo, Richard C. Robinson, Robert J. Gatchel

Physical Medicine & Rehabilitation

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis is believed to be a valid biological marker of stress. This study evaluating changes in patients with temporomandibular disorders (TMD) and low back pain (LBP) to determine whether dysregulation of this system represents a marker for chronicity. Salivary cortisol samples were collected from 78 patients (TMD = 41, LBP = 37) upon waking up and 20 minutes later daily for 2 weeks. High-risk patients for chronic pain had different overall cortisol levels versus low-risk patients. High-risk patients exhibited greater variability in terms of cortisol secretion compared with low-risk patients, F(1, 1,243) = 17.73, p <.000. These results provide evidence of a neuroendocrine mechanism underlying a constellation of psychosocial risk factors for chronic pain.

Original language	English (US)
Pages (from-to)	166-178
Number of pages	13
Journal	Journal of Applied Biobehavioral Research
Volume	11
Issue number	3-4
DOIs	https://doi.org/10.1111/j.1751-9861.2007.00003.x
State	Published - 2006

ASJC Scopus subject areas

Cultural Studies
Experimental and Cognitive Psychology
Clinical Psychology
Social Sciences (miscellaneous)

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10.1111/j.1751-9861.2007.00003.x

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title = "Hypothalamic-pituitary-adrenocortical axis dysregulation in acute temporomandibular disorder and low back pain: A marker for chronicity?",

abstract = "Dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis is believed to be a valid biological marker of stress. This study evaluating changes in patients with temporomandibular disorders (TMD) and low back pain (LBP) to determine whether dysregulation of this system represents a marker for chronicity. Salivary cortisol samples were collected from 78 patients (TMD = 41, LBP = 37) upon waking up and 20 minutes later daily for 2 weeks. High-risk patients for chronic pain had different overall cortisol levels versus low-risk patients. High-risk patients exhibited greater variability in terms of cortisol secretion compared with low-risk patients, F(1, 1,243) = 17.73, p <.000. These results provide evidence of a neuroendocrine mechanism underlying a constellation of psychosocial risk factors for chronic pain.",

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Hypothalamic-pituitary-adrenocortical axis dysregulation in acute temporomandibular disorder and low back pain: A marker for chronicity?

Abstract

ASJC Scopus subject areas

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