Hypothalamic-pituitary-adrenocortical axis dysregulation in acute temporomandibular disorder and low back pain: A marker for chronicity?

John P. Garofalo, Richard C. Robinson, Robert J. Gatchel

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis is believed to be a valid biological marker of stress. This study evaluating changes in patients with temporomandibular disorders (TMD) and low back pain (LBP) to determine whether dysregulation of this system represents a marker for chronicity. Salivary cortisol samples were collected from 78 patients (TMD = 41, LBP = 37) upon waking up and 20 minutes later daily for 2 weeks. High-risk patients for chronic pain had different overall cortisol levels versus low-risk patients. High-risk patients exhibited greater variability in terms of cortisol secretion compared with low-risk patients, F(1, 1,243) = 17.73, p <.000. These results provide evidence of a neuroendocrine mechanism underlying a constellation of psychosocial risk factors for chronic pain.

Original languageEnglish (US)
Pages (from-to)166-178
Number of pages13
JournalJournal of Applied Biobehavioral Research
Volume11
Issue number3-4
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Cultural Studies
  • Experimental and Cognitive Psychology
  • Clinical Psychology
  • Social Sciences (miscellaneous)

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