Hypothermia for neonatal hypoxic–ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field

Seetha Shankaran, Girija Natarajan, Lina Chalak, Athina Pappas, Scott A. McDonald, Abbot R. Laptook

Research output: Contribution to journalArticle

8 Scopus citations


In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalSeminars in Perinatology
Issue number6
Publication statusPublished - Oct 1 2016



  • Biomarkers
  • Hypothermia Neuroprotection
  • Hypoxic-ischemic encephalopathy
  • Neonatal

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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