Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism

B. O. Anderson, E. E. Moore, F. A. Moore, J. A. Leff, L. S. Terada, A. H. Harken, J. E. Repine

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (~30% blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham- treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.

Original languageEnglish (US)
Pages (from-to)1862-1865
Number of pages4
JournalJournal of applied physiology
Volume71
Issue number5
DOIs
StatePublished - 1991

Keywords

  • adult respiratory distress syndrome
  • ischemia- reperfusion
  • myeloperoxidase
  • oxygen radicals
  • vascular injury

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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