Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism

B. O. Anderson, E. E. Moore, F. A. Moore, J. A. Leff, L. S. Terada, A. H. Harken, J. E. Repine

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (~30% blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham- treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.

Original languageEnglish (US)
Pages (from-to)1862-1865
Number of pages4
JournalJournal of Applied Physiology
Volume71
Issue number5
StatePublished - 1991

Fingerprint

Xanthine Oxidase
Shock
Neutrophils
Lung
Phlebotomy
Peroxidase
Arterial Pressure
Diet
Tungsten

Keywords

  • adult respiratory distress syndrome
  • ischemia- reperfusion
  • myeloperoxidase
  • oxygen radicals
  • vascular injury

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Anderson, B. O., Moore, E. E., Moore, F. A., Leff, J. A., Terada, L. S., Harken, A. H., & Repine, J. E. (1991). Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism. Journal of Applied Physiology, 71(5), 1862-1865.

Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism. / Anderson, B. O.; Moore, E. E.; Moore, F. A.; Leff, J. A.; Terada, L. S.; Harken, A. H.; Repine, J. E.

In: Journal of Applied Physiology, Vol. 71, No. 5, 1991, p. 1862-1865.

Research output: Contribution to journalArticle

Anderson, BO, Moore, EE, Moore, FA, Leff, JA, Terada, LS, Harken, AH & Repine, JE 1991, 'Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism', Journal of Applied Physiology, vol. 71, no. 5, pp. 1862-1865.
Anderson, B. O. ; Moore, E. E. ; Moore, F. A. ; Leff, J. A. ; Terada, L. S. ; Harken, A. H. ; Repine, J. E. / Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism. In: Journal of Applied Physiology. 1991 ; Vol. 71, No. 5. pp. 1862-1865.
@article{5d985b5cc6cf4db482724685eded1f6a,
title = "Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism",
abstract = "Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (~30{\%} blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham- treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.",
keywords = "adult respiratory distress syndrome, ischemia- reperfusion, myeloperoxidase, oxygen radicals, vascular injury",
author = "Anderson, {B. O.} and Moore, {E. E.} and Moore, {F. A.} and Leff, {J. A.} and Terada, {L. S.} and Harken, {A. H.} and Repine, {J. E.}",
year = "1991",
language = "English (US)",
volume = "71",
pages = "1862--1865",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism

AU - Anderson, B. O.

AU - Moore, E. E.

AU - Moore, F. A.

AU - Leff, J. A.

AU - Terada, L. S.

AU - Harken, A. H.

AU - Repine, J. E.

PY - 1991

Y1 - 1991

N2 - Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (~30% blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham- treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.

AB - Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (~30% blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham- treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.

KW - adult respiratory distress syndrome

KW - ischemia- reperfusion

KW - myeloperoxidase

KW - oxygen radicals

KW - vascular injury

UR - http://www.scopus.com/inward/record.url?scp=0025937815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025937815&partnerID=8YFLogxK

M3 - Article

VL - 71

SP - 1862

EP - 1865

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 5

ER -