Hypoxia mediates tumor malignancy and therapy resistance

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Hypoxia is a hallmark of the tumor microenvironment and contributes to tumor malignant phenotypes. Hypoxia-inducible factor (HIF) is a master regulator of intratumoral hypoxia and controls hypoxia-mediated pathological processes in tumors, including angiogenesis, metabolic reprogramming, epigenetic reprogramming, immune evasion, pH homeostasis, cell migration/invasion, stem cell pluripotency, and therapy resistance. In this book chapter, we reviewed the causes and types of intratumoral hypoxia, hypoxia detection methods, and the oncogenic role of HIF in tumorigenesis and chemo- and radio-therapy resistance.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages1-18
Number of pages18
DOIs
Publication statusPublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1136
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Angiogenesis
  • Cell motility
  • Epigenetics
  • HIF
  • Hypoxia
  • Hypoxia imaging
  • Metabolism
  • Stem cell
  • Therapy resistance
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Luo, W., & Wang, Y. (2019). Hypoxia mediates tumor malignancy and therapy resistance. In Advances in Experimental Medicine and Biology (pp. 1-18). (Advances in Experimental Medicine and Biology; Vol. 1136). Springer New York LLC. https://doi.org/10.1007/978-3-030-12734-3_1