Hypoxia-regulated microRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma

Hung Lung Ke, Wei Ming Li, Hui Hui Lin, Wei Chi Hsu, Ya Ling Hsu, Lin Li Chang, Chun Nung Huang, Ching Chia Li, Hsin Ping Chang, Hsin Chih Yeh, Chien Feng Li, Wen Jeng Wu

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1α (HIF-1α) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1α was analyzed statistically. Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1α is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001). Conclusion: Both miR-210 and HIF-1α are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism.

Original languageEnglish (US)
Pages (from-to)578-584
Number of pages7
JournalInternational Journal of Medical Sciences
Volume14
Issue number6
DOIs
StatePublished - May 11 2017
Externally publishedYes

Keywords

  • HIF-1α
  • MiR-210
  • Upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Medicine(all)

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