Hypoxia-regulated microRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma

Hung Lung Ke; Wei Ming Li; Hui Hui Lin; Wei Chi Hsu; Ya Ling Hsu; Lin Li Chang; Chun Nung Huang; Ching Chia Li; Hsin Ping Chang; Hsin Chih Yeh; Chien Feng Li; Wen Jeng Wu

doi:10.7150/ijms.15699

Hypoxia-regulated microRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma

Hung Lung Ke, Wei Ming Li, Hui Hui Lin, Wei Chi Hsu, Ya Ling Hsu, Lin Li Chang, Chun Nung Huang, Ching Chia Li, Hsin Ping Chang, Hsin Chih Yeh, Chien Feng Li, Wen Jeng Wu

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17 Scopus citations

Abstract

Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1α (HIF-1α) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1α was analyzed statistically. Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1α is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001). Conclusion: Both miR-210 and HIF-1α are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism.

Original language	English (US)
Pages (from-to)	578-584
Number of pages	7
Journal	International Journal of Medical Sciences
Volume	14
Issue number	6
DOIs	https://doi.org/10.7150/ijms.15699
State	Published - May 11 2017
Externally published	Yes

Keywords

HIF-1α
MiR-210
Upper tract urothelial carcinoma

ASJC Scopus subject areas

Medicine(all)

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10.7150/ijms.15699

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Ke, H. L., Li, W. M., Lin, H. H., Hsu, W. C., Hsu, Y. L., Chang, L. L., Huang, C. N., Li, C. C., Chang, H. P., Yeh, H. C., Li, C. F., & Wu, W. J. (2017). Hypoxia-regulated microRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma. International Journal of Medical Sciences, 14(6), 578-584. https://doi.org/10.7150/ijms.15699

@article{e4ad7101941f4f64ba5b33dde568f52b,

title = "Hypoxia-regulated microRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma",

abstract = "Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1α (HIF-1α) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1α was analyzed statistically. Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1α is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001). Conclusion: Both miR-210 and HIF-1α are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism.",

keywords = "HIF-1α, MiR-210, Upper tract urothelial carcinoma",

author = "Ke, {Hung Lung} and Li, {Wei Ming} and Lin, {Hui Hui} and Hsu, {Wei Chi} and Hsu, {Ya Ling} and Chang, {Lin Li} and Huang, {Chun Nung} and Li, {Ching Chia} and Chang, {Hsin Ping} and Yeh, {Hsin Chih} and Li, {Chien Feng} and Wu, {Wen Jeng}",

note = "Funding Information: This study was supported by grants from Kaohsiung Medical University ?Aim for the Top Universities? (KMU-TP104E31, KMU-TP105G00, KMU-TP105G01, KMU-TP105G02), the health and welfare surcharge of tobacco products, Ministry of Health and Welfare (MOHW105-TDU-B-212-134007), Ministry of Science and Technology (MOST103-2314-B-037-059-MY3), and Kaohsiung Medical University Hospital (KMUH102-2M41, KMUH102-2R40, KMUH101-1R46). Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",

year = "2017",

month = may,

day = "11",

doi = "10.7150/ijms.15699",

language = "English (US)",

volume = "14",

pages = "578--584",

journal = "International Journal of Medical Sciences",

issn = "1449-1907",

publisher = "Ivyspring International Publisher",

number = "6",

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TY - JOUR

T1 - Hypoxia-regulated microRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma

AU - Ke, Hung Lung

AU - Li, Wei Ming

AU - Lin, Hui Hui

AU - Hsu, Wei Chi

AU - Hsu, Ya Ling

AU - Chang, Lin Li

AU - Huang, Chun Nung

AU - Li, Ching Chia

AU - Chang, Hsin Ping

AU - Yeh, Hsin Chih

AU - Li, Chien Feng

AU - Wu, Wen Jeng

N1 - Funding Information: This study was supported by grants from Kaohsiung Medical University ?Aim for the Top Universities? (KMU-TP104E31, KMU-TP105G00, KMU-TP105G01, KMU-TP105G02), the health and welfare surcharge of tobacco products, Ministry of Health and Welfare (MOHW105-TDU-B-212-134007), Ministry of Science and Technology (MOST103-2314-B-037-059-MY3), and Kaohsiung Medical University Hospital (KMUH102-2M41, KMUH102-2R40, KMUH101-1R46). Publisher Copyright: © Ivyspring International Publisher.

PY - 2017/5/11

Y1 - 2017/5/11

N2 - Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1α (HIF-1α) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1α was analyzed statistically. Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1α is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001). Conclusion: Both miR-210 and HIF-1α are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism.

AB - Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1α (HIF-1α) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1α was analyzed statistically. Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1α is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001). Conclusion: Both miR-210 and HIF-1α are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism.

KW - HIF-1α

KW - MiR-210

KW - Upper tract urothelial carcinoma

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DO - 10.7150/ijms.15699

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AN - SCOPUS:85019641728

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JF - International Journal of Medical Sciences

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ER -

Hypoxia-regulated microRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma

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