Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs

Medicine & Life Sciences

• Lanosterol 100%
• 3-hydroxy-3-methylglutaryl-coenzyme A 83%
• Oxidoreductases 58%
• Hypoxia 50%
• Cholesterol 46%
• Hypoxia-Inducible Factor 1 32%
• Oxygen 27%
• lanostenol 26%
• Endoplasmic Reticulum-Associated Degradation 18%
• Hydroxymethylglutaryl CoA Reductases 17%
• Demethylation 15%
• Sterols 14%
• Endoplasmic Reticulum 12%
• Transcription Factors 9%
• Enzymes 6%
• Proteins 4%

Chemical Compounds

• Lanosterol 91%
• Cholesterol 57%
• 24,25-dihydrolanosterol 25%
• 3-Hydroxy-3-Methylglutaryl-CoA 20%
• Demethylation 15%
• Sterol 13%
• Mammalian Cell 13%
• Dioxygen 12%
• Rate-Determining Step 12%
• Methyl Group 10%
• Metabolite 8%
• Amount 5%
• Protein 5%
• Molecule 4%