Hypoxic-ischemic brain injury in the term infant-current concepts

Lina Shalak; Jeffrey M. Perlman

doi:10.1016/j.earlhumdev.2004.06.003

Hypoxic-ischemic brain injury in the term infant-current concepts

Lina Shalak, Jeffrey M. Perlman

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.

Original language	English (US)
Pages (from-to)	125-141
Number of pages	17
Journal	Early Human Development
Volume	80
Issue number	2
DOIs	https://doi.org/10.1016/j.earlhumdev.2004.06.003
State	Published - Nov 2004

Keywords

Hypoxic-ischemic brain injury
Infant-current concepts cerebral palsy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1016/j.earlhumdev.2004.06.003

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abstract = "An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.",

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AB - An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.

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Hypoxic-ischemic brain injury in the term infant-current concepts

Abstract

Keywords

ASJC Scopus subject areas

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