Hypoxic-ischemic brain injury in the term infant-current concepts

Lina Shalak, Jeffrey M. Perlman

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.

Original languageEnglish (US)
Pages (from-to)125-141
Number of pages17
JournalEarly Human Development
Issue number2
StatePublished - Nov 2004


  • Hypoxic-ischemic brain injury
  • Infant-current concepts cerebral palsy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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