I believe I can Fly! Use of drosophila as a model organism in neuropsychopharmacology research

Anjana S. Narayanan, Adrian Rothenfluh

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Neuropsychiatric disorders are of complex etiology, often including a large genetic component. In order to help identify and study the molecular and physiological mechanisms that such genes participate in, numerous animal models have been established in a variety of species. Over the past decade, this has increasingly included the vinegar fly, Drosophila melanogaster. Here, we outline why we study an invertebrate organism in the context of neuropsychiatric disorders, and we discuss how we can gain insight from studies in Drosophila. We focus on a few disorders and findings to make the larger point that modeling these diseases in flies can have both mechanistic and predictive validity. Highlighting some translational examples, we underline the fact that their brains works more like ours than one would have anticipated.

Original languageEnglish (US)
Pages (from-to)1439-1446
Number of pages8
JournalNeuropsychopharmacology
Volume41
Issue number6
DOIs
StatePublished - May 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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