I believe I can Fly!

Use of drosophila as a model organism in neuropsychopharmacology research

Anjana S. Narayanan, Adrian Rothenfluh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Neuropsychiatric disorders are of complex etiology, often including a large genetic component. In order to help identify and study the molecular and physiological mechanisms that such genes participate in, numerous animal models have been established in a variety of species. Over the past decade, this has increasingly included the vinegar fly, Drosophila melanogaster. Here, we outline why we study an invertebrate organism in the context of neuropsychiatric disorders, and we discuss how we can gain insight from studies in Drosophila. We focus on a few disorders and findings to make the larger point that modeling these diseases in flies can have both mechanistic and predictive validity. Highlighting some translational examples, we underline the fact that their brains works more like ours than one would have anticipated.

Original languageEnglish (US)
Pages (from-to)1439-1446
Number of pages8
JournalNeuropsychopharmacology
Volume41
Issue number6
DOIs
StatePublished - May 1 2016

Fingerprint

Diptera
Drosophila
Invertebrates
Drosophila melanogaster
Research
Acetic Acid
Animal Models
Brain
Genes

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

I believe I can Fly! Use of drosophila as a model organism in neuropsychopharmacology research. / Narayanan, Anjana S.; Rothenfluh, Adrian.

In: Neuropsychopharmacology, Vol. 41, No. 6, 01.05.2016, p. 1439-1446.

Research output: Contribution to journalArticle

@article{fe883dc0749c413eba46fa20e287a81a,
title = "I believe I can Fly!: Use of drosophila as a model organism in neuropsychopharmacology research",
abstract = "Neuropsychiatric disorders are of complex etiology, often including a large genetic component. In order to help identify and study the molecular and physiological mechanisms that such genes participate in, numerous animal models have been established in a variety of species. Over the past decade, this has increasingly included the vinegar fly, Drosophila melanogaster. Here, we outline why we study an invertebrate organism in the context of neuropsychiatric disorders, and we discuss how we can gain insight from studies in Drosophila. We focus on a few disorders and findings to make the larger point that modeling these diseases in flies can have both mechanistic and predictive validity. Highlighting some translational examples, we underline the fact that their brains works more like ours than one would have anticipated.",
author = "Narayanan, {Anjana S.} and Adrian Rothenfluh",
year = "2016",
month = "5",
day = "1",
doi = "10.1038/npp.2015.322",
language = "English (US)",
volume = "41",
pages = "1439--1446",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - I believe I can Fly!

T2 - Use of drosophila as a model organism in neuropsychopharmacology research

AU - Narayanan, Anjana S.

AU - Rothenfluh, Adrian

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Neuropsychiatric disorders are of complex etiology, often including a large genetic component. In order to help identify and study the molecular and physiological mechanisms that such genes participate in, numerous animal models have been established in a variety of species. Over the past decade, this has increasingly included the vinegar fly, Drosophila melanogaster. Here, we outline why we study an invertebrate organism in the context of neuropsychiatric disorders, and we discuss how we can gain insight from studies in Drosophila. We focus on a few disorders and findings to make the larger point that modeling these diseases in flies can have both mechanistic and predictive validity. Highlighting some translational examples, we underline the fact that their brains works more like ours than one would have anticipated.

AB - Neuropsychiatric disorders are of complex etiology, often including a large genetic component. In order to help identify and study the molecular and physiological mechanisms that such genes participate in, numerous animal models have been established in a variety of species. Over the past decade, this has increasingly included the vinegar fly, Drosophila melanogaster. Here, we outline why we study an invertebrate organism in the context of neuropsychiatric disorders, and we discuss how we can gain insight from studies in Drosophila. We focus on a few disorders and findings to make the larger point that modeling these diseases in flies can have both mechanistic and predictive validity. Highlighting some translational examples, we underline the fact that their brains works more like ours than one would have anticipated.

UR - http://www.scopus.com/inward/record.url?scp=84963614493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963614493&partnerID=8YFLogxK

U2 - 10.1038/npp.2015.322

DO - 10.1038/npp.2015.322

M3 - Article

VL - 41

SP - 1439

EP - 1446

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 6

ER -