Ia-bearing macrophages in athymic mice: Antigen presentation and regulation

C. Y. Lu, E. Peters, E. R. Unanue

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Ia-bearing macrophages from spleens and peritoneal cavities of athymic (nu/nu) and euthymic (nu/+) were compared. Macrophages from both strains of mice had equal antigen-presenting ability. The basal numbers of unstimulated Ia-bearing peritoneal macrophages were equal, but only euthymic mice recruited large numbers of Ia-bearing macrophages after Listeria infection. The i.p. injections of a 'macrophage Ia-recruiting factor' induced exudates rich in Ia-bearing macrophages in both athymic and euthymic mice. These data suggest 2 levels of control of Ia-bearing macrophages: a basal T cell-independent level and a stimulated level dependent on mature T cell.

Original languageEnglish (US)
Pages (from-to)2496-2498
Number of pages3
JournalJournal of Immunology
Volume126
Issue number6
StatePublished - 1981

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Antigen Presentation
Nude Mice
Macrophages
T-Lymphocytes
Listeriosis
Peritoneal Cavity
Peritoneal Macrophages
Exudates and Transudates
Spleen
Antigens
Injections

ASJC Scopus subject areas

  • Immunology

Cite this

Ia-bearing macrophages in athymic mice : Antigen presentation and regulation. / Lu, C. Y.; Peters, E.; Unanue, E. R.

In: Journal of Immunology, Vol. 126, No. 6, 1981, p. 2496-2498.

Research output: Contribution to journalArticle

Lu, CY, Peters, E & Unanue, ER 1981, 'Ia-bearing macrophages in athymic mice: Antigen presentation and regulation', Journal of Immunology, vol. 126, no. 6, pp. 2496-2498.
Lu, C. Y. ; Peters, E. ; Unanue, E. R. / Ia-bearing macrophages in athymic mice : Antigen presentation and regulation. In: Journal of Immunology. 1981 ; Vol. 126, No. 6. pp. 2496-2498.
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