Ia-bearing macrophages in athymic mice: Antigen presentation and regulation

C. Y. Lu, E. Peters, E. R. Unanue

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Ia-bearing macrophages from spleens and peritoneal cavities of athymic (nu/nu) and euthymic (nu/+) were compared. Macrophages from both strains of mice had equal antigen-presenting ability. The basal numbers of unstimulated Ia-bearing peritoneal macrophages were equal, but only euthymic mice recruited large numbers of Ia-bearing macrophages after Listeria infection. The i.p. injections of a 'macrophage Ia-recruiting factor' induced exudates rich in Ia-bearing macrophages in both athymic and euthymic mice. These data suggest 2 levels of control of Ia-bearing macrophages: a basal T cell-independent level and a stimulated level dependent on mature T cell.

Original languageEnglish (US)
Pages (from-to)2496-2498
Number of pages3
JournalJournal of Immunology
Volume126
Issue number6
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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