Identification and characterization of β-sitosterol target proteins

Brett Lomenick, Heping Shi, Jing Huang, Chuo Chen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.

Original languageEnglish (US)
Pages (from-to)4976-4979
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number21
DOIs
StatePublished - Nov 1 2015

Keywords

  • 17β-HSD4
  • E-Syt1
  • Phytosterol
  • Target identification
  • β-Sitosterol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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