Identification and Partial Purification of a Factor That Stimulates Calcium-Dependent Proteases

George N. DeMartino, Donald K. Blumenthal

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

We have identified and partially purified from bovine brain a factor which stimulates the activities of two rat liver calcium-dependent proteases. The factor, which is physically and functionally distinct from calmodulin, is heat stable and has a low apparent molecular weight (Mr 20000). The factor stimulates rates of proteolysis up to 25-fold but does not alter the calcium sensitivity of either protease. We have called this factor calcium-dependent protease regulator.

Original languageEnglish (US)
Pages (from-to)4297-4303
Number of pages7
JournalBiochemistry
Volume21
Issue number18
DOIs
StatePublished - Aug 1982

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Identification and Partial Purification of a Factor That Stimulates Calcium-Dependent Proteases'. Together they form a unique fingerprint.

  • Cite this