We have identified and partially purified from bovine brain a factor which stimulates the activities of two rat liver calcium-dependent proteases. The factor, which is physically and functionally distinct from calmodulin, is heat stable and has a low apparent molecular weight (Mr 20000). The factor stimulates rates of proteolysis up to 25-fold but does not alter the calcium sensitivity of either protease. We have called this factor calcium-dependent protease regulator.
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