Identification of a hormonal basis for gallbladder filling

Mihwa Choi, Antonio Moschetta, Angie L. Bookout, Li Peng, Michihisa Umetani, Sam R. Holmstrom, Kelly Suino-Powell, H. Eric Xu, James A. Richardson, Robert D. Gerard, David J. Mangelsdorf, Steven A. Kliewer

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.

Original languageEnglish (US)
Pages (from-to)1253-1255
Number of pages3
JournalNature Medicine
Volume12
Issue number11
DOIs
StatePublished - Nov 2006

Fingerprint

Gallbladder
Gallbladder Emptying
Fibroblast Growth Factors
Bile Acids and Salts
Bile
Small Intestine
Intestines
Digestion
Hormones

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Choi, M., Moschetta, A., Bookout, A. L., Peng, L., Umetani, M., Holmstrom, S. R., ... Kliewer, S. A. (2006). Identification of a hormonal basis for gallbladder filling. Nature Medicine, 12(11), 1253-1255. https://doi.org/10.1038/nm1501

Identification of a hormonal basis for gallbladder filling. / Choi, Mihwa; Moschetta, Antonio; Bookout, Angie L.; Peng, Li; Umetani, Michihisa; Holmstrom, Sam R.; Suino-Powell, Kelly; Xu, H. Eric; Richardson, James A.; Gerard, Robert D.; Mangelsdorf, David J.; Kliewer, Steven A.

In: Nature Medicine, Vol. 12, No. 11, 11.2006, p. 1253-1255.

Research output: Contribution to journalArticle

Choi, M, Moschetta, A, Bookout, AL, Peng, L, Umetani, M, Holmstrom, SR, Suino-Powell, K, Xu, HE, Richardson, JA, Gerard, RD, Mangelsdorf, DJ & Kliewer, SA 2006, 'Identification of a hormonal basis for gallbladder filling', Nature Medicine, vol. 12, no. 11, pp. 1253-1255. https://doi.org/10.1038/nm1501
Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR et al. Identification of a hormonal basis for gallbladder filling. Nature Medicine. 2006 Nov;12(11):1253-1255. https://doi.org/10.1038/nm1501
Choi, Mihwa ; Moschetta, Antonio ; Bookout, Angie L. ; Peng, Li ; Umetani, Michihisa ; Holmstrom, Sam R. ; Suino-Powell, Kelly ; Xu, H. Eric ; Richardson, James A. ; Gerard, Robert D. ; Mangelsdorf, David J. ; Kliewer, Steven A. / Identification of a hormonal basis for gallbladder filling. In: Nature Medicine. 2006 ; Vol. 12, No. 11. pp. 1253-1255.
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