@article{83654d28d5ca4c56bd9123b47d71ff33,
title = "Identification of a hormonal basis for gallbladder filling",
abstract = "The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.",
author = "Mihwa Choi and Antonio Moschetta and Bookout, {Angie L.} and Li Peng and Michihisa Umetani and Holmstrom, {Sam R.} and Kelly Suino-Powell and Xu, {H. Eric} and Richardson, {James A.} and Gerard, {Robert D.} and Mangelsdorf, {David J.} and Kliewer, {Steven A.}",
note = "Funding Information: We thank T. Reh (University of Washington) for the Fgf15–/– mice; J. Shelton, the Pathology Core Group, and members of S.A.K. and D.J.M.{\textquoteright}s laboratories for technical assistance; and S. Cary for graphics. This work was funded by US National Institutes of Health grants DK067158 (S.A.K.) and U19DK62434 (S.A.K., D.J.M. and H.E.X.), the Robert A. Welch Foundation (S.A.K. and D.J.M.), the Jay and Betty Van Andel Foundation (H.E.X.) and the Howard Hughes Medical Institute (D.J.M.). D.J.M. is an investigator of the Howard Hughes Medical Institute.",
year = "2006",
month = nov,
doi = "10.1038/nm1501",
language = "English (US)",
volume = "12",
pages = "1253--1255",
journal = "Nature medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "11",
}