Identification of a hormonal basis for gallbladder filling

Mihwa Choi, Antonio Moschetta, Angie L. Bookout, Li Peng, Michihisa Umetani, Sam R. Holmstrom, Kelly Suino-Powell, H. Eric Xu, James A. Richardson, Robert D. Gerard, David J. Mangelsdorf, Steven A. Kliewer

Research output: Contribution to journalArticle

192 Scopus citations

Abstract

The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.

Original languageEnglish (US)
Pages (from-to)1253-1255
Number of pages3
JournalNature medicine
Volume12
Issue number11
DOIs
StatePublished - Nov 1 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Choi, M., Moschetta, A., Bookout, A. L., Peng, L., Umetani, M., Holmstrom, S. R., Suino-Powell, K., Xu, H. E., Richardson, J. A., Gerard, R. D., Mangelsdorf, D. J., & Kliewer, S. A. (2006). Identification of a hormonal basis for gallbladder filling. Nature medicine, 12(11), 1253-1255. https://doi.org/10.1038/nm1501