TY - JOUR
T1 - Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors
AU - Zhang, Yuan
AU - Repa, Joyce J.
AU - Inoue, Yusuke
AU - Hayhurst, Graham P.
AU - Gonzalez, Frank J.
AU - Mangelsdorf, David J.
PY - 2004/4
Y1 - 2004/4
N2 - In this work, we report the characterization of a novel liver-specific gene (L-UrdPase), whose expression is regulated by a number of hepatic nuclear receptors (including liver X receptors, peroxisome proliferator-activated receptor α, farnesoid X receptor, and hepatic nuclear factor-4α), which have been shown to be involved in lipid metabolism. L-UrdPase encodes a previously uncharacterized protein with similarity to an intestine-specific uridine phosphorylase. Enzymatic assays confirmed that L-UrdPase has uridine phosphorylase activity. However, L-UrdPase has a highly restricted, nonoverlapping pattern of expression with its intestinal counterpart and is regulated in a distinct manner by several different nuclear receptors. The identification of the liver uridine phosphorylase and its characterization as a target of lipid-sensing nuclear receptors implies the existence of a previously unknown nuclear receptor signaling pathway that links lipid and uridine metabolism.
AB - In this work, we report the characterization of a novel liver-specific gene (L-UrdPase), whose expression is regulated by a number of hepatic nuclear receptors (including liver X receptors, peroxisome proliferator-activated receptor α, farnesoid X receptor, and hepatic nuclear factor-4α), which have been shown to be involved in lipid metabolism. L-UrdPase encodes a previously uncharacterized protein with similarity to an intestine-specific uridine phosphorylase. Enzymatic assays confirmed that L-UrdPase has uridine phosphorylase activity. However, L-UrdPase has a highly restricted, nonoverlapping pattern of expression with its intestinal counterpart and is regulated in a distinct manner by several different nuclear receptors. The identification of the liver uridine phosphorylase and its characterization as a target of lipid-sensing nuclear receptors implies the existence of a previously unknown nuclear receptor signaling pathway that links lipid and uridine metabolism.
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U2 - 10.1210/me.2003-0285
DO - 10.1210/me.2003-0285
M3 - Article
C2 - 14715930
AN - SCOPUS:1842478960
SN - 0888-8809
VL - 18
SP - 851
EP - 862
JO - Molecular Endocrinology
JF - Molecular Endocrinology
IS - 4
ER -