Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors

Yuan Zhang, Joyce J. Repa, Yusuke Inoue, Graham P. Hayhurst, Frank J. Gonzalez, David J. Mangelsdorf

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

In this work, we report the characterization of a novel liver-specific gene (L-UrdPase), whose expression is regulated by a number of hepatic nuclear receptors (including liver X receptors, peroxisome proliferator-activated receptor α, farnesoid X receptor, and hepatic nuclear factor-4α), which have been shown to be involved in lipid metabolism. L-UrdPase encodes a previously uncharacterized protein with similarity to an intestine-specific uridine phosphorylase. Enzymatic assays confirmed that L-UrdPase has uridine phosphorylase activity. However, L-UrdPase has a highly restricted, nonoverlapping pattern of expression with its intestinal counterpart and is regulated in a distinct manner by several different nuclear receptors. The identification of the liver uridine phosphorylase and its characterization as a target of lipid-sensing nuclear receptors implies the existence of a previously unknown nuclear receptor signaling pathway that links lipid and uridine metabolism.

Original languageEnglish (US)
Pages (from-to)851-862
Number of pages12
JournalMolecular Endocrinology
Volume18
Issue number4
DOIs
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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