Identification of a nuclear receptor for bite acids

Makoto Makishima, Arthur Y. Okamoto, Joyce J. Repa, Hua Tu, R. Marc Learned, Alvin Luk, Mitchell V. Hull, Kevin D. Lustig, David J. Mangelsdorf, Bei Shan

Research output: Contribution to journalArticle

1741 Citations (Scopus)

Abstract

Bite acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bite acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bite acids, FXR repressed transcription of the gene encoding cholesterol 7α- hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid-binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.

Original languageEnglish (US)
Pages (from-to)1362-1365
Number of pages4
JournalScience
Volume284
Issue number5418
DOIs
StatePublished - May 21 1999

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Bites and Stings
Cytoplasmic and Nuclear Receptors
Bile Acids and Salts
Acids
Cholesterol 7-alpha-Hydroxylase
Orphan Nuclear Receptors
Genes
Cholesterol
Ligands
Lipids
Enzymes
bile acid binding proteins

ASJC Scopus subject areas

  • General

Cite this

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., ... Shan, B. (1999). Identification of a nuclear receptor for bite acids. Science, 284(5418), 1362-1365. https://doi.org/10.1126/science.284.5418.1362

Identification of a nuclear receptor for bite acids. / Makishima, Makoto; Okamoto, Arthur Y.; Repa, Joyce J.; Tu, Hua; Learned, R. Marc; Luk, Alvin; Hull, Mitchell V.; Lustig, Kevin D.; Mangelsdorf, David J.; Shan, Bei.

In: Science, Vol. 284, No. 5418, 21.05.1999, p. 1362-1365.

Research output: Contribution to journalArticle

Makishima, M, Okamoto, AY, Repa, JJ, Tu, H, Learned, RM, Luk, A, Hull, MV, Lustig, KD, Mangelsdorf, DJ & Shan, B 1999, 'Identification of a nuclear receptor for bite acids', Science, vol. 284, no. 5418, pp. 1362-1365. https://doi.org/10.1126/science.284.5418.1362
Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A et al. Identification of a nuclear receptor for bite acids. Science. 1999 May 21;284(5418):1362-1365. https://doi.org/10.1126/science.284.5418.1362
Makishima, Makoto ; Okamoto, Arthur Y. ; Repa, Joyce J. ; Tu, Hua ; Learned, R. Marc ; Luk, Alvin ; Hull, Mitchell V. ; Lustig, Kevin D. ; Mangelsdorf, David J. ; Shan, Bei. / Identification of a nuclear receptor for bite acids. In: Science. 1999 ; Vol. 284, No. 5418. pp. 1362-1365.
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