Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development

Agriculture & Biology

• calpain 100%
• drug development 98%
• Plasmodium falciparum 92%
• screening 54%
• antimalarials 12%
• malaria 10%
• parasites 10%
• Plasmodium 5%
• cysteine proteinases 5%
• amino acids 5%
• assays 5%
• proteinase inhibitors 5%
• gelatin 5%
• catalytic activity 4%
• active sites 4%
• moieties 4%
• hemoglobin 4%
• mutation 3%
• prediction 3%
• drugs 3%
• degradation 3%
• synthesis 2%
• enzymes 2%
• methodology 1%

Medicine & Life Sciences

• Calpain 95%
• Plasmodium falciparum 81%
• Drug Development 72%
• calpain inhibitors 27%
• Parasites 15%
• Antimalarials 14%
• Malaria 11%
• Amino Acids 9%
• Pharmaceutical Preparations 7%
• Cysteine Proteases 7%
• Catalysis 7%
• Plasmodium 7%
• Gelatin 6%
• Fluorescent Dyes 6%
• Protease Inhibitors 6%
• Catalytic Domain 5%
• Hemoglobins 5%
• Mutation 3%
• Enzymes 3%