Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target

Hanjing Wei; Yanhua Xu; Yibin Wang; Liting Xu; Chunyang Mo; Liangzi Li; Bo Shen; Yao Sun; Pengzhen Cheng; Liu Yang; Yichuan Pang; An Qin; Ying Cao; Sean J. Morrison; Rui Yue

doi:10.1016/j.celrep.2020.108252

Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target

Hanjing Wei, Yanhua Xu, Yibin Wang, Liting Xu, Chunyang Mo, Liangzi Li, Bo Shen, Yao Sun, Pengzhen Cheng, Liu Yang, Yichuan Pang, An Qin, Ying Cao, Sean J. Morrison, Rui Yue

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Wei et al. find that Fap is an osteogenic suppressor that could be targeted to promote bone formation and inhibit bone resorption. Genetic and pharmacological inhibition of Fap attenuates aging- and ovariectomy-induced bone loss in mice, while Osteolectin functions as an endogenous inhibitor of Fap to promote mineralization in zebrafish.

Original language	English (US)
Article number	108252
Journal	Cell Reports
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2020.108252
State	Published - Oct 13 2020

Keywords

Clec11a
Fap
bone formation
bone resorption
mineralization
osteogenesis
osteolectin
osteoporosis
zebrafish

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108252

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title = "Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target",

abstract = "Wei et al. find that Fap is an osteogenic suppressor that could be targeted to promote bone formation and inhibit bone resorption. Genetic and pharmacological inhibition of Fap attenuates aging- and ovariectomy-induced bone loss in mice, while Osteolectin functions as an endogenous inhibitor of Fap to promote mineralization in zebrafish.",

keywords = "Clec11a, Fap, bone formation, bone resorption, mineralization, osteogenesis, osteolectin, osteoporosis, zebrafish",

author = "Hanjing Wei and Yanhua Xu and Yibin Wang and Liting Xu and Chunyang Mo and Liangzi Li and Bo Shen and Yao Sun and Pengzhen Cheng and Liu Yang and Yichuan Pang and An Qin and Ying Cao and Morrison, {Sean J.} and Rui Yue",

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T1 - Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target

AU - Wei, Hanjing

AU - Xu, Yanhua

AU - Wang, Yibin

AU - Xu, Liting

AU - Mo, Chunyang

AU - Li, Liangzi

AU - Shen, Bo

AU - Sun, Yao

AU - Cheng, Pengzhen

AU - Yang, Liu

AU - Pang, Yichuan

AU - Qin, An

AU - Cao, Ying

AU - Morrison, Sean J.

AU - Yue, Rui

PY - 2020/10/13

Y1 - 2020/10/13

N2 - Wei et al. find that Fap is an osteogenic suppressor that could be targeted to promote bone formation and inhibit bone resorption. Genetic and pharmacological inhibition of Fap attenuates aging- and ovariectomy-induced bone loss in mice, while Osteolectin functions as an endogenous inhibitor of Fap to promote mineralization in zebrafish.

AB - Wei et al. find that Fap is an osteogenic suppressor that could be targeted to promote bone formation and inhibit bone resorption. Genetic and pharmacological inhibition of Fap attenuates aging- and ovariectomy-induced bone loss in mice, while Osteolectin functions as an endogenous inhibitor of Fap to promote mineralization in zebrafish.

KW - Clec11a

KW - Fap

KW - bone formation

KW - bone resorption

KW - mineralization

KW - osteogenesis

KW - osteolectin

KW - osteoporosis

KW - zebrafish

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Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target

Abstract

Keywords

ASJC Scopus subject areas

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