Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target

Hanjing Wei, Yanhua Xu, Yibin Wang, Liting Xu, Chunyang Mo, Liangzi Li, Bo Shen, Yao Sun, Pengzhen Cheng, Liu Yang, Yichuan Pang, An Qin, Ying Cao, Sean J. Morrison, Rui Yue

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Wei et al. find that Fap is an osteogenic suppressor that could be targeted to promote bone formation and inhibit bone resorption. Genetic and pharmacological inhibition of Fap attenuates aging- and ovariectomy-induced bone loss in mice, while Osteolectin functions as an endogenous inhibitor of Fap to promote mineralization in zebrafish.

Original languageEnglish (US)
Article number108252
JournalCell Reports
Volume33
Issue number2
DOIs
StatePublished - Oct 13 2020

Keywords

  • Clec11a
  • Fap
  • bone formation
  • bone resorption
  • mineralization
  • osteogenesis
  • osteolectin
  • osteoporosis
  • zebrafish

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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