Identification of hyperthyroid patients by means of a sensitive assay for thyrotropin

J. S. Malter, S. E. Manotti, G. R. Knee, D. B. Goodman, J. F. Strauss

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Abstract

We evaluated a new assay (TSH3 MAIAclone) for thyrotropin (TSH) with improved sensitivity, testing a series of hospital inpatients with increased free thyroxin indices (thyroxin concentration x triiodothyronine uptake on resin). This assay involves use of three monoclonal antibodies and an antibody-magnetic particle conjugate that rapidly and completely separates bound and free tracer in a magnetic field. The assay turnaround time is 3 h. By the TSH3-MAIAclone assay, 65% of these patients with an increased free thyroxin index were identified on the basis of a TSH value ≤0.50 milli-int. unit/L. In contrast, another commercially available assay for TSH detected suppressed TSH concentrations in less than 5% of these patients. We conclude that the TSH3 MAIAclone assay markedly improves our ability to discriminate hyperthyroidism from euthyroidism.

Original languageEnglish (US)
Pages (from-to)642-644
Number of pages3
JournalClinical chemistry
Volume31
Issue number4
StatePublished - Dec 1 1985

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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Malter, J. S., Manotti, S. E., Knee, G. R., Goodman, D. B., & Strauss, J. F. (1985). Identification of hyperthyroid patients by means of a sensitive assay for thyrotropin. Clinical chemistry, 31(4), 642-644.