@article{e48c2b1d85ef4328aca58e547d310393,
title = "Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013",
abstract = "Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.",
author = "Sareth Rith and Davis, {C. Todd} and Veasna Duong and Borann Sar and Horm, {Srey Viseth} and Savuth Chin and Sovann Ly and Denis Laurent and Beat Richner and Ikwo Oboho and Yunho Jang and William Davis and Sharmi Thor and Amanda Balish and Iuliano, {A. Danielle} and San Sorn and Davun Holl and Touch Sok and Heng Seng and Arnaud Tarantola and Reiko Tsuyuoka and Amy Parry and Nora Chea and Lotfi Allal and Paul Kitsutani and Dora Warren and Michael Prouty and Paul Horwood and Widdowson, {Marc Alain} and Stephen Lindstrom and Julie Villanueva and Ruben Donis and Nancy Cox and Philippe Buchy",
note = "Publisher Copyright: {\textcopyright}2014, American Society for Microbiology.",
year = "2014",
doi = "10.1128/JVI.01887-14",
language = "English (US)",
volume = "88",
pages = "13897--13909",
journal = "Journal of virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "23",
}