Identification of new markers for the Schistosoma mansoni vitelline lineage

Jipeng Wang, James J. Collins

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Schistosomes cause significant morbidity and mortality in millions of the world's poorest people. While parasite egg-induced inflammation is the primary driver of host pathology, relatively little is known at the molecular level about the organ systems that participate in schistosome egg production (i.e., testes, ovaries and vitellaria). Here we use transcriptional profiling and in situ hybridization to characterise the vitellarium of Schistosoma mansoni. We uncovered several previously uncharacterised vitellaria-specific factors and defined molecular markers for various stages in the vitellocyte differentiation process. These data provide the framework for future in-depth molecular studies exploring the biology of this important parasite organ.

Original languageEnglish (US)
JournalInternational Journal for Parasitology
DOIs
StateAccepted/In press - Mar 3 2016

Fingerprint

Schistosoma mansoni
Ovum
Parasites
In Situ Hybridization
Testis
Ovary
Pathology
Inflammation
Morbidity
Mortality

Keywords

  • Reproduciton
  • Schistosoma
  • Stem cell
  • Vitellaria

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

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AB - Schistosomes cause significant morbidity and mortality in millions of the world's poorest people. While parasite egg-induced inflammation is the primary driver of host pathology, relatively little is known at the molecular level about the organ systems that participate in schistosome egg production (i.e., testes, ovaries and vitellaria). Here we use transcriptional profiling and in situ hybridization to characterise the vitellarium of Schistosoma mansoni. We uncovered several previously uncharacterised vitellaria-specific factors and defined molecular markers for various stages in the vitellocyte differentiation process. These data provide the framework for future in-depth molecular studies exploring the biology of this important parasite organ.

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